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Cellular Memory Laboratory
Yoichi SHINKAI
Chief Scientist
Yoichi SHINKAI (M.D.)
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Research Areas

Our laboratory's principal objective is to understand the molecular mechanism of epigenetic gene regulation and the role of epigenetics in health and disease. To address these topics, we take multidisciplinary approaches, including molecular biology, biochemistry, cell biology, structural biology and mouse molecular genetics.

Research Subject

  1. Studies for epigenetic regulation of biological processes
  2. Biology of protein lysine methylation
  3. Elucidation of molecular mechanisms of human diseases by utilizing novel animal models

Related links

  1. RIKEN Advanced Science Institute Website_Laboratories PageNew Window

List of Selected Publications

  1. Shinkai, Y., and Tachibana, M.:
    "H3K9 Methyltransferase G9a and the Related Molecule GLP."
    Genes Dev. 2011, 25:781-788.
  2. Matsui, T., Leung, D., Miyashita, H., Maksakova, I.A., Miyachi, H., Kimura, H., Tachibana, M., Lorincz, M.C., and Shinkai, Y.:
    "Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET."
    Nature. 2010, 464:927-931.
  3. Inagaki, T., Tachibana, M., Magoori, K., Kudo, H., Tanaka, T., Okamura, M., Naito, M. Kodama., T. Shinkai, Y., and Sakai, Y.:
    "Obesity and metabolic syndrome in histone demethylase JHDM2a deficient mice. "
    Genes to Cells, 2009, 14:991-1001
  4. Tachibana M., Matsumura Y., Fukuda M., Kimura H., and Shinkai Y.:
    "G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription."
    EMBO J. 2008, 27:2681-2690.
  5. Tachibana, M., Nozaki, M., Takeda, N., and Shinkai, Y.:
    "Functional dynamics of H3K9 methylation during meiotic prophase progression."
    EMBO J. 2007, 26:3346-3359.
  6. Tachibana, M., Ueda, J., Fukuda, M., Takeda, N., Ohta, T., Iwanari, H., Sakihama, T., Kodama, T., Hamakubo, T., and Shinkai, Y.:
    "Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9."
    Gene Dev. 2005, 19:815-826.
  7. Tachibana, M., Sugimoto, K., Nozaki, M., Ueda, J., Ohta, T., Ohki, M., Fukuda, M., Takeda, N., Niida, H., Kato, H., and Shinkai, Y.:
    "G9a histone methyltransferase plays a dominant role for euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis."
    Gene Dev. 2002, 16:1779-1791.
  8. Tachibana, M., Sugimoto, K., Fukushima, T., and Shinkai, Y.:
    "with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3"
    J. Biol. Chem. 2001, 276:25309-25317.

Members

Principal Investigator

Yoichi SHINKAI
Chief Scientist

Staff Scientist

Tadahiro SHIMAZU
Research Scientist
Atsuko SHIRAI
Research Scientist

Postdoctoral Fellow

Ayumi YAMADA
Contract Researcher
Masaki KATO
Contract Researcher

Student Trainee

Daisuke MURAMATSU
Junior Research Associate

Technical Assistant

Mikiko FUKUDA
Technical Staff I