Laboratories
Home > Laboratories > Advanced Science Institute > Chemical Biology Department > Chemical Biology Core Facility > Collaboration Promotion Team
Collaboration Promotion Team
Tamio SAITO
Team Head
Tamio SAITO (D.Agr.)
mail
Lab Homepage

Click

Research Areas

A chemical library, which is rich in structural diversity, is an indispensable tool in promoting drug-discovery and chemical biology researches. To be able to make an effective use of the chemical library, we develop a system and foundation of chemical bank "Natural Products Depository (NPDepo)", and promote reserch supports and collaborative studies on the basis of research infrastructures and techniques of NPDepo.

Research Subject

  1. Promotion of collaboration and support trough supply of chemical library
  2. Promotion of research supports by high-throughput screening and validation of biological activities
  3. Research support by structure-activity relationship analysis and optimization of compound structures

List of Selected Publications

  1. Y. Yashiroda, R. Okamoto, K. Hatsugai, Y. Takemoto, N. Goshima, T. Saito, M. Hamamoto, Y. Sugimoto, H. Osada, H. Seimiya, and M. Yoshida:
    "A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor"
    Biochem Biophys Res Commun, 394, 569-573 (2010)
  2. A. Yoneda, T. Ito, T. Higaki, N. Kutsuna, T. Saito, T. Ishimizu, H. Osada, S. Hasezawa, M. Matsui, T. Demura,:
    "Cobtorin target analysis reveals that pectin functions in deposition of cellulose microfibrils parallel to cortical microtubules in a manner dependent on the methylesterification ratio of pectin and its distribution"
    Plant J., 64, 657-667 (2010).
  3. K. Tanaka, K. Nakamura, T. Saito, H. Osada, A. Hirai, H. Takahashi, S. Kanaya, Md.Altaf-Ul-Amin:
    "Metabolic pathway prediction based on inclusive relation between cyclic substructures."
    Plant Biotechnology, 26, 459-468, 2009.
  4. T. Saito, T. Nogawa, N. Kato, Y. Kondo, H.Osada:
    "Construction of natural products library and its usage for drug discovery."
    Protein, Nucleic acid and Enzyme (in Japanese) , 54, 1551-1556.(2009)
  5. T. Saito, Z. Lepp, H. Osada:
    "Chemical screening database."
    The Lung Perspective(in Japanese),17, 283-288.(2009)
  6. Y. Sato, H. Kamiyama, T. Usui, T. Saito, H. Osada, S. Kuwahara, H. Kiyota:
    "Synthesis and anti-angiogenic activity of cortistatin analogs."
    Biosci. Biotech. Biochem., 72, 2992-2997, (2008)
Page Top