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Chemical Biology Core Facility
Research Areas
To promote "Chemical Biological Research" that aims to elucidate biological phenomena using chemical compounds as starting materials, chemical libraries and databases that describe the chemical and biological information of the libraries must be appropriately maintained. Our facility will construct chemical libraries and databases through the genetic and organic chemical researches of secondary metabolites from actinomycetes and fungi. We will also promote basic research to validate the usefulness of the chemical library, to identify the molecular target of the active compound, and to elucidate the mechanism behind the action of the active compounds in the libraries. We will continue to maintain infrastructure for chemical biological studies. Five research teams involved in this facility are to cooperate together closely and actively, in order to promote the missions of the research program. 		 

Hiroyuki OSADA
Laboratory Director
Hiroyuki OSADA (D.Agr.)
mail


Research Subject
(1) Construction of a chemical bank, "Natural Products Depository (NPDepo)".
(2) Expansion of the chemical library using genetic engineering and synthetic chemistry.
(3) Evaluation of the chemical library through high throughput screening systems.
(4) Structural analyses of small molecules, proteins and their complexes using high technologies.
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List of Selected Publications
(1) Osada, H. and Hertweck, C.:
"Exploring the chemical space of microbial natural products."
Curr Opin Chem Biol, 13: 133-134 (2009)
(2) Kawatani, M., Okumura, H., Honda, K., Kanoh, N., Muroi, M., Dohmae, N., Takami, M., Kitagawa, M., Futamura, Y., Imoto, M., and Osada, H.:
"The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I."
Proc. Natl. Acad. Sci. USA., 105, 11691-11696 (2008)
(3) Yano, A., Tsutsumi, S., Soga, S., Lee, M. J., Trepel, J., Osada, H., and Neckers, L.:
"Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone."
J. Biol. Chem., 283:28607-28617 (2008)
(4) Kurokawa, K., Lee, H., Roh, KB., Asanuma, M., Kim, YS., Nakayama, H., Shiratsuchi, A., Choi, Y., Takeuchi, O., Kang, HJ., Dohmae, N., Nakanishi, Y., Akira, S., Sekimizu, K., and Lee, BL.:
"The Triacylated ATP Binding Cluster Transporter Substrate-binding Lipoprotein of Staphylococcus aureus Functions as a Native Ligand for Toll-like Receptor 2."
J Biol Chem. 27; 284(13):8406-11 (2009)
(5) Ye, Y.Q., Koshino, H., Onose, J., Yoshikawa, K., Abe, N., and Takahashi, S.:
"Expeditious synthesis of vialinin B, an extremely potent inhibitor of TNF-α production."
Org. Lett., 11, 5074-5077 (2009)








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