Chemical Biology Core Facility
Laboratory Director
Hiroyuki OSADA (D.Agr.)
To promote "Chemical Biological Research" that aims to elucidate biological phenomena using chemical compounds as starting materials, chemical libraries and databases that describe the chemical and biological information of the libraries must be appropriately maintained. Our facility will construct chemical libraries and databases through the genetic and organic chemical researches of secondary metabolites from actinomycetes and fungi. We will also promote basic research to validate the usefulness of the chemical library, to identify the molecular target of the active compound, and to elucidate the mechanism behind the action of the active compounds in the libraries. We will continue to maintain infrastructure for chemical biological studies. Five research teams involved in this facility are to cooperate together closely and actively, in order to promote the missions of the research program.
- Construction of a chemical bank, "Natural Products Depository (NPDepo)".
- Expansion of the chemical library using genetic engineering and synthetic chemistry.
- Evaluation of the chemical library through high throughput screening systems.
- Structural analyses of small molecules, proteins and their complexes using high technologies.
- August 12, 2008
- Clarification of an inhibiting factor for the differentiation to osteoclasts in bone metabolism
- Miyazaki, I., Simizu, S., & Osada, H.:
"A small-molecule inhibitor shows that pirin regulates migration of melanoma cells."
Nature Chem. Biol., 6,667-673,(2010) - Sun, Y., Hahn, F., Demydchuk, Y., Chettle, J., Tosin, M., Osada, H.,and Leadlay, P. F.:
"In vitro reconstruction of tetronate RK-682 biosynthesis."
Nature Chem. Biol, 6, 99-101 (2010) - Osada, H., and Hertweck, C.:
"Exploring the chemical space of microbial natural products."
Curr. Opin. Chem. Biol, 13, 133-134 (2009) - Kawatani, M., Okumura, H., Honda, K., Kanoh, N., Muroi, M., Dohmae, N., Takami, M., Kitagawa, M., Futamura, Y., Imoto, M.,and Osada, H.:
"The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I."
Proc. Natl. Acad. Sci. USA., 105, 11691-11696 (2008) - Yano, A., Tsutsumi, S., Soga, S., Lee, M. J., Trepel, J., Osada, H.,and Neckers, L.:
"Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone."
Proc. Natl. Acad. Sci. USA., 105, 15541-15546 (2008) - Kurokawa, K., Lee, H., Roh, KB., Asanuma, M., Kim, YS., Nakayama, H., Shiratsuchi, A., Choi, Y., Takeuchi, O., Kang, HJ., Dohmae, N., Nakanishi, Y., Akira, S., Sekimizu, K.,and Lee, BL.:
"The triacylated ATP binding cluster transporter substrate-binding lipoprotein of Staphylococcus aureus functions as a native ligand for Toll-like receptor 2."
J. Biol. Chem. 27, 284, 8406-11 (2009)
