Laboratories
Home > Laboratories > Advanced Science Institute > Chemical Biology Department > Chemical Biology Core Facility > Collaboration Promotion Team
Collaboration Promotion Team
Tamio SAITO
Team Head
Tamio SAITO (D.Agr.)
mail Click

Research Areas

Chemical library is one of the indispensable tools to promote drug-discovery with the strategy of chemical biology. To ensure utilization and application of the chemical library, we develop a foundation of chemical bank "Natural Products Depository (NPDepo)". On the basis of the NPDepo foundation, we promote collaborative researches in wide range of research fields such as chemical biology, chemistry and biology, and supports the researchers by provision and deposition of chemical library, validation of biological activities, structure-activity relationship analysis. Moreover we will develop the support system including characterization of small molecules and biological macromolecules by cooperation with Molecular characterization team and Biomolecular characterization team.

Research Subject

  1. Collaborative research and support through supply of chemical library
  2. Promotion of research supports by high-throughput screening and validation of biological activities
  3. Research support by structure-activity relationship analysis and optimization of compound structures

Related links

  1. RIKEN Advanced Science Institute Website_Laboratories PageNew Window
  2. Individual Website Laboratory PageNew Window

List of Selected Publications

  1. R. Ishitsuka, T. Saito, H. Osada, Y. Ohno-Iwashita, T. Kobayashi,:
    "Fluorescence image screening for chemical compounds modifying cholesterol metabolism and distribution"
    J Lipid Res. 52, 2084-2094 (2011)
  2. A. Yoneda, T. Ito, T. Higaki, N. Kutsuna, T. Saito, T. Ishimizu, H. Osada, S. Hasezawa, M. Matsui, T. Demura,:
    "Cobtorin target analysis reveals that pectin functions in deposition of cellulose microfibrils parallel to cortical microtubules in a manner dependent on the methylesterification ratio of pectin and its distribution"
    Plant J., 64, 657-667 (2010).
  3. Y. Yashiroda, R. Okamoto, K. Hatsugai, Y. Takemoto, N. Goshima, T. Saito, M. Hamamoto, Y. Sugimoto, H. Osada, H. Seimiya, and M. Yoshida,:
    "A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor"
    Biochem Biophys Res Commun, 394, 569-573 (2010)
  4. K. Tanaka, K. Nakamura, T. Saito, H. Osada, A. Hirai, H. Takahashi, S. Kanaya, Md.Altaf-Ul-Amin,:
    "Metabolic pathway prediction based on inclusive relation between cyclic substructures."
    Plant Biotechnology, 26, 459-468, 2009.

Members

Principal Investigator

Tamio SAITO
Team Head

Postdoctoral Fellow

Hiroshi HIROTA
Contract Researcher

Technical Assistant

Ayumi IKENO
Technical Staff I
Atsuko NIHONYANAGI
Technical Staff I
Yuta YAMAZAKI
Technical Staff I
Kozue YOSHINARI
Technical Staff II
Page Top