Tissue Response Control Materials Laboratory

Our laboratory is established in April. 2011, for promotion of collaboration of RIKEN and the Zeon Medical Co. Ltd. under the program for collaboration with industry of the center of intellectual property strategies. Our main research subject is the novel artificial organs using ion beam technology. Polymeric materials have contributed significantly to the development and improvement of medical devices and systems. Various interactions take place between biomaterials and a body when polymeric biomaterials come into contact with a living organism. Ion implantation is a physicochemical surface modification process that results from the impingement of a high-energy ion beam. Newly designed polymers using ion-beam modification methods have been studied to improve blood and tissue compatibility for the fabrication of novel artificial organs.

Research Subjects

• Development of materials for small vessel anastomosis.
• Development of materials for a great and middle vessel anastomosis.
• Development of materials for physiological nerve regeneration.
• Development of materials for reconstruction organs.
• Development of anti-thrombogenic materials.

Publications

1. Tanaka Toshiyuki, Tsuchiya Koji, Yajima Hirofumi, Suzuki Yoshiaki ,Fukutome Akira:
   "In vitro degradation properties of ion-beam irradiated poly(lactide-co-glycolic acid) mesh"
   Nuclear Instruments and Methods in Physics Research B Vol.269, 19 pp. 2130-2132 (2011)
2. Tanaka Toshiyuki, Ujiie Rena, Yajima Hirofumi, Mizutani Kyoichiro, Suzuki Yoshiaki, Sakuragi Hitoshi:
   "Ion-beam irradiation into biodegradable nanofibers for tissue engineering scaffolds"
   Surface and Coatings Technology Vol.206, 5 pp889-892 (2011)
3. Tanaka Toshiyuki, Yajima Hirofumi, Ujiie Hirosh,i Suzuki Yoshiaki, Fukutome Akira:
   "Ion beam irradiation of polyglactin mesh for improving biocompatibility"
   Transactions of the Materials Research Society of Japan Vol.36, 3 pp297-300 (2011)
4. Morisaki Shinya, Ogura Atsushi, Hamago Shunsuke, Tanaka Toshiyuki, Mizutani Kyoichiro, Yamada Akari, Suzuki Yoshiaki:
   "Biocompatible evaluation of ion-beam irradiated PTFE Felt"
   Transactions of the Materials Research Society of Japan Vol.37 2 pp251-254 (2012)
5. Tanaka Toshiyuki, Suzuki Yoshiaki, Tsuchiya Kouji, Yajima Hirofumi:
   "Surface characterization and assessment of cell attachment capabilities of thin films fabricated by ion-beam irradiation of poly(l-lactic acid) substrates"
   Applied Surface Science Vol.265 pp281-285 (2013)