Intestinal Microbe Symbiosis Research Laboratory

In recent years, the interest in probiotic lactic acid bacteria and these impacts on the intestinal flora and host are growing. Objective of the present study is to understand the probiotic health benefits of lactic acid bacteria in gastrointestinal (GI) tract throughout the study of these roles in GI tract. Especially, changes in intestinal immune system in response to probiotic lactic acid bacterial interaction are main target for our study. We also study mouse immunomodulatory effects, such as anti-allergic effect and immnostumulatory effects after treatment of lactic acid bacteria.

Research Subjects

• Evaluation of adhesive activities of probiotic lactic acid bacteria to mouse gastrointestinal tract
• Analysis of adhesive activity of lactic acid bacteria to intestinal immune system
• Comparative analysis of the activities for different lactic acid bacteria and active components

Publications

1. Yanagihara S, Fukuda S, Ohno H, Yamamoto N.:
   "Exposure to probiotic Lactobacillus acidophilus L-92 modulates gene expression profiles of epithelial Caco-2 cells."
   J Med Food. 2012 Jun;15(6):511-9. doi: 10.1089/jmf.2012.0040. Epub 2012 Apr 17.