Laboratory for Multiscale Biosystem Dynamics

We study multi-scale dynamics in biological systems, such as differentiation and evolution, using both theoretical and experimental approaches. For example, we analyze phenotypic/genetic changes of microorganisms during experimental evolution, to unveil interplay between dynamics of adaptation and evolution. We also study dynamics differentiation process of stem cells using theoretical models, to understand how cell-cell interactions bring about cellular diversifications and robust development of multicellular systems.

Research Subjects

• Analysis of developmental process using theoretical cell models
• Study of evolutionary dynamics of microorganisms by comprehensive phenotypic/genetic analysis
• Development of algorithm for high-resolution comprehensive phenotypic/genetic analysis

Publications

1. * Furusawa C and Kaneko K.:
   "A dynamical-systems view of stem cell biolog"
   Science 338(6104), 205 (2012)
2. * Furusawa C and Kaneko K.:
   "Adaptation to optimal cell growth through self-organized criticality"
   Phys. Rev. Lett. 108, 208103 (2012)
3. * Horinouchi, K. Tamaoka, C. Furusawa, N. Ono, S. Suzuki, T. Hirasawa, T. Yomo and H. Shimizu:
   "Transcriptome analysis of parallel-evolved Escherichia coli strains under ethanol stress"
   BMC Genomics, 11, 579 (2010)
4. * Furusawa C and Kaneko K.:
   "Theory of robustness of irreversible differentiation in a stem cell system: chaos hypothesis"
   J. Theor. Biol. 209, 395-416 (2001)
5. * Furusawa C, Ono N, Suzuki S, Agata T, Shimizu H, and Yomo T.:
   "Model-based analysis of non-specific binding for background correction of high-density oligonucleotide microarrays"
   Bioinformatics, 25(1), 34-61 (2009)
6. * Furusawa C and Kaneko K.:
   "Zipf's law in gene expression"
   Phys. Rev. Lett., 90, 088102 (2003)