Laboratory for Integrated Biodevice

This unit aims "on-chip cell creation". We promote integration and sophistication of biological experiments based on micro fabrication technology (MEMS) and fluid control technology using physically and chemically stable glass as a material which is accommodated for chemical synthesis and detection, and ultimately aim to construct a platform for synthesis of bio-molecules that form cells by realizing single cell, single molecule handling. Furthermore, our original target is to design and make models of cells using micro and nano channels and structures by bottom up method, and to create new principle device exploiting unique functions of cells or tissue. By these approaches, we will pioneer and develop a new field "integrated biodevice engineering" which especially focuses on this center's mission, "whole cell modeling".

Research Subjects

• Integration and sophistication of biological experiments
• Single molecule synthesis, separation and analysis
• Artificial cell creation using micro and nano space
• Novel micro/nano device development exploiting biological functions

Publications

1. * Tanaka Y., Yanagisawa Y., Kitamori, T.:
   "Fluid actuation for a bio-micropump powered by previously frozen cardiomyocytes directly seeded on a diagonally stretched thin membrane"
   Sens. Actuators B, Chem., 156, 494-498 (2011)
2. * Tanaka, Y., Xi H., Sato K., Mawatari K., Renberg B., Nilsson M., Kitamori T.:
   "microchannels for analysis of small sample volumes""
   Anal. Chem., 83, 3352-3357 (2011)
3. * Yamashita T., Tanaka Y., Idota N., Sato K., Mawatari K., Kitamori T.:
   "Cultivation and recovery of vascular endothelial cells in microchannels of a separable micro-chemical chip"
   Biomaterials, 32, 2459-2465 (2011)
4. * Jang, K., Sato, K., Tanaka, Y., Xu, Y., Mawatari, K., Sato, M., Nakajima, T., Konno, T., Ishihara, K., Kitamori, T.:
   "An efficient surface modification by 2-methacryloyloxyethyl phosphorylcholine for selective control of cell attachment using photochemical reaction in microchannel"
   Lab Chip, 10, 1937-1945 (2010)
5. * Tanaka, Y., Sato K., Kitamori T.:
   "Assembly and simple demonstration of a micropump installing PDMS-based thin membranes as flexible micro check valves"
   J. Boimed. Nanotechnol., 5, 516-520 (2009)
6. * Tanaka, Y., Sato, K., Shimizu, T., Yamato, M., Okano, T., Manabe, I., Nagai, R., Kitamori T.:
   "Demonstration of a bio-microactuator powered by vascular smooth muscle cells coupled to polymer micropillars"
   Lab Chip, 8, 58-61 (2008)
7. * Tanaka, Y., Kikukawa, Y., Sato, K., Sugii, Y., Kitamori, T.:
   "Culture and leukocyte adhesion assay of human arterial endothelial cells in a glass microchip"
   Anal. Sci., 23, 261-266 (2007)
8. * Tanaka, Y., Sato, K., Shimizu, T., Yamato, M., Okano, T., Kitamori, T.:
   "A micro-spherical heart pump powered by cultured cardiomyocytes"
   Lab Chip, 7, 207-212 (2007)
9. * Tanaka, Y., Morishima, K., Shimizu, T., Kikuchi, A., Yamato, M., Okano, T., Kitamori, T.:
   "An actuated pump on-chip powered by cultured cardiomyocytes"
   Lab Chip, 6, 362-368 (2006)
10. * Tanaka, Y., Morishima, K., Shimizu, T., Kikuchi, A., Yamato, M., Okano T., Kitamori, T.:
    "Demonstration of a PDMS-based bio-microactuator using cultured cardiomyocytes to drive polymer micropillars"
    Lab Chip, 6, 230-235 (2006)