Yu Initiative Research Unit

Synthetic organic chemistry contributes tremendous to the development of material science, ranging from polymers to organic electronics. Research in our group intends to develop a multidisciplinary research program involving the triad of chemistry, electronic materials, and biomedical/biological investigations based on molecular and nano-assembled building blocks of organic conductive materials. These materials introduce electrical characteristics to build up the complexity necessary for further understanding of the targeted biological/biomedical issues. On the other hand, a thorough understanding of the relationship between the molecular/nanostructural characteristics of organic conductive materials with its potential in biological application would explore another dimension of synthetic organic chemistry and polymer chemistry. Ultimately, our research effort would be engaged toward new areas in biomaterials science and engineering through the angle of synthetic organic chemistry.

Research Subjects

• Anti-fouling conducting polymer biointerfaces as smart surface
• Molecular building blocks for hydrophilic conducting polymers
• Functional and nanostrucured surfaces for cell capturing

Publications

1. Zhao, H.; Liu, C.-H.; Luo, S.-C.; Zhu, B.; Wang, T.-H.; Hsu, H.-F.; Yu, Hsiao-hua:
   "Facile syntheses of dioxythiophene-based conjugated polymers by direct C-H arylation"
   Macromolecules 2012, 45, 7783-7790
2. Luo, S.-C.; Sekine, J.; Zhu, B.; Zhao, H.; Nakao, A.; Yu, Hsiao-hua:
   "Polydioxythiophene nanodots, nanotubes, nanowires and nano-networks by template-free electropolymerization - the effect of functional groups and temperature"
   ACS Nano 2012, 6, 3018-3026
3. Sekine, J.; Luo, S.-C.; Wang, S.; Zhu, B.; Tseng, H.R.; Yu, Hsiao-hua:
   "Functionalized conducting polymer nanodots for enhanced cell capturing: the synergistic effect of capture agents and nanostructures"
   Adv. Mater. 2011, 23, 4788-4792
4. Liu, C.-Y.; Zhao, H.; Yu, Hsiao-hua:
   "Efficient synthesis of 3,4-Ethylenedioxythiophene (EDOT)-based functional π-conjugated molecules through direct C-H bond arylations"
   Org. Lett. 2011, 13, 4068-4071
5. Tansil, N. C.; Kantchev, E. A. B.; Gao, Z.; Yu, Hsiao-hua:
   "Electropolymerization of intercalator-grafted conducting polymer for direct and amplified DNA detection"
   Chem. Commun. 2011, 47, 1533-1535
6. Luo, S.-C.; Liour, S. S.; Yu, Hsiao-hua:
   "Perfluoro-functionalized PEDOT films with controlled morphology as superhydrophobic coatings and biointerfaces with enhanced cell adhesion"
   Chem. Commun. 2010, 46, 4731-4733
7. Xie, H.; Luo, S.-C.; Yu, Hsiao-hua
   "Electric-filed assisted growth of functionalized poly(3,4-ethylenedioxythiophene) nanowires for label-free protein detection"
   Small 2009, 5, 2611-2617
8. Hou, S.; Zhao, H.; Zhao, L.; Shen, Q.; Wei, K. S.; Suh D. Y.; Nakao, A.; Xiong B.; Luo, S.-C.; Tseng, H.-R.; Yu, Hsiao-hua:
   "Capture and stimulated release of circulating tumor cells on polymer grafted silicon nanostructures"
   Adv. Mater. DOI: 10.1002/adma.201203185
9. Lin, H.-A.; Luo, S.-C.; Zhu, B.; Yamashita, Y.; Yu, Hsiao-hua:
   "Molecular Structures or Nano-assemblies? The Deciding Factor of Surface Properties in Poly(3,4-ethylenedioxythiophene) Nanorod Array"
   Adv. Funct. Mater. DOI: 10.1002/adfm.201203006
10. 4. Luo, S.-C.; Zhu, B.; Kantchev, E. A. B.; Siang, Y. W.; Yu, Hsiao-hua:
    "Tunable, dynamic and electrically stimulated lectin-carbohydrate recognition on a glycan-grafted conjugated polymer"
    Chem. Commun. 2012, 48, 6942-6944