Research Summary

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

• 1. *Travaglini KJ, Nabhan AN, Penland L, Sinha R, Gillich A, Sit RV, Chang S, Conley SD, Mori Y, Seita J, Berry GJ, Shrager JB, Metzger RJ, Kuo CS, Neff N, Weissman IL, Quake SQ, Krasnow MA.:
  "A molecular cell atlas of the human lung from single cell RNA sequencing"
  Nature 587(7835):619 (2020)
• 2. Yazaki J, Kawashima Y, Ogawa T, Kobayashi A, Okoshi M, Watanabe T, Yoshida S, Kii I, Egami S, Amagai M, Hosoya T, Shiroguchi K, Ohara O.:
  "HaloTag-based conjugation of proteins to barcoding-oligonucleotides"
  Nucleic Acids Res. 48(2):e8 (2020)
• 3. Shimizu K, Sato Y, Kawamura M, Nakazato H, Watanabe T, Ohara O, Fujii SI.:
  "Eomes transcription factor is required for the development and differentiation of invariant NKT cells"
  Commun Biol. 2(1):150 (2019)
• 4. Kawashima Y, Watanabe E, Umeyama T, Nakajima D, Hattori M, Honda K, Ohara O.:
  "Optimization of Data-Independent Acquisition Mass Spectrometry for Deep and Highly Sensitive Proteomic Analysis"
  Int J Mol Sci. 20(23) 5932 (2019)
• 5. Kawashima Y, Miyata J, Watanabe T, Shioya J, Arita M, Ohara O.:
  "Proteogenomic Analyses of Cellular Lysates Using a Phenol-Guanidinium Thiocyanate Reagent"
  J Proteome Res. 18(1), 301-308 (2019)
• 6. Rosental B, Kowarsky M, Seita J, Corey DM, Ishizuka KJ, Palmeri KJ, Chen SY, Sinha R, Okamoto J, Mantalas G, Manni L, Raveh T, Clarke DN, Tsai JM, Newman AM, Neff NF, Nolan GP, Quake SR, Weissman IL, Voskoboynik A.:
  "Complex mammalian-like haematopoietic system found in a colonial chordate”
  Nature. 564(7736) 425 (2018)
• 7. Kawashima Y, Ohara O.:
  "Development of a NanoLC-MS/MS System Using a Nonporous Reverse Phase Column for Ultrasensitive Proteome Analysis"
  Anal Chem. 90(21), 12334-12338 (2018)
• 8. Saito Y, Mochizuki Y, Ogahara I, Watanabe T, Hogdal L, Takagi S, Sato K, Kaneko A, Kajita H, Uchida N, Fukami T, Shultz LD, Taniguchi S, Ohara O, Letai AG, Ishikawa F.:
  "Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways"
  Sci Transl Med. 9(413):eaao1214 (2017)
• 9. Fujiki R, Hijikata A, Shirai T, Okada S, Kobayashi M, Ohara O.:
  "Molecular mechanism and structural basis of gain-of-function of STAT1 caused by pathogenic R274Q mutation"
  J Biol Chem. 292(15):6240-6254 (2017)
• 10. Yakushiji-Kaminatsui N, Kondo T, Endo TA, Koseki Y, Kondo K, Ohara O, Vidal M, Koseki H.:
  "RING1 proteins contribute to early proximal-distal specification of the forelimb bud by restricting Meis2 expression."
  Development. 143(2), 276-85 (2016)

Recent Research Results

• 

  Feb. 21, 2020
  An efficient DNA-tagging strategy to assist early detection of disease signatures

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