Research Summary

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

• 1.Thaiss CA, Levy M, Korem T, Dohnalová L, Shapiro H, Jaitin DA, David E, Winter DR, Gury-BenAri M, Tatirovsky E, Tuganbaev T, Federici S, Zmora N, Zeevi D, Dori-Bachash, M., Pevsner-Fischer, M., Kartvelishvily, E., Brandis, A., Harmelin, A., Shibolet O, Halpern Z, Honda K, Amit I, Segal, E, Elinav E:
  "Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations."
  Cell, 167(6):1495-1510 (2016).
• 2.Mathewson ND, Jenq R, Mathew AV, Koenigsknecht M, Hanash A, Toubai T, Oravecz-Wilson K, Wu SR, Sun Y, Rossi C, Fujiwara H, Byun J, Shono Y, Lindemans C, Calafiore M, Schmidt TC, Honda K, Young VB, Pennathur S, van den Brink M, Reddy P:
  "Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease."
  Nat. Immunol. 17(5):505 (2016).
• 3.Honda K, Littman DR:
  "The microbiota in adaptive immune homeostasis and disease."
  Nature, 535:75-84 (2016).
• 4.Ramanan D, Bowcutt R, Lee SC, Tang MS, Kurtz ZD, Ding Y, Honda K, Gause WC, Blaser MJ, Bonneau RA, Lim YA, Loke P, Cadwell K:
  "Helminth infection promotes colonization resistance via type 2 immunity."
  Science, 352(6285):608-612 (2016).
• 5.Tanoue T, Atarashi K, Honda K:
  "Development and maintenance of intestinal regulatory T cells."
  Nat. Rev. Immunol., 16(5):295-309 (2016).
• 6.Atarashi K, Tanoue T, Ando M, Kamada N, Nagano Y, Narushima S, Suda W, Imaoka A, Setoyama H, Nagamori T, Ishikawa E, Shima T, Hara T, Kado S, Jinnohara T, Ohno H, Kondo T, Toyooka K, Watanabe E, Yokoyama S, Tokoro S, Mori H, Noguchi Y, Morita H, Ivanov II, Sugiyama T, Nuñez G, Camp JG, Hattori M, Umesaki Y, Honda K:
  "Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells."
  Cell, 163:367-380 (2015).
• 7.Atarashi K, Tanoue T, Oshima K, Suda W, Nagano Y, Nishikawa H, Fukuda S, Saito T, Narushima S, Hase K, Kim S, Fritz JV, Wilmes P, Ueha S, Matsushima K, Ohno H, Olle B, Sakaguchi S, Taniguchi T, Morita H, Hattori M, Honda K:
  "Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota."
  Nature, 500:232-236 (2013).
• 8.Honda K, Littman DR:
  "The microbiome in infectious disease and inflammation."
  Annu Rev Immunol., 30:759-95 (2012).
• 9.*Atarashi K, Tanoue T, Shima T, Imaoka A, Kuwahara T, Momose Y, Cheng G, Yamasaki S, Saito T, Ohba Y, Taniguchi T, Takeda K, Hori S, Ivanov II, Umesaki Y, Itoh K, Honda K:
  "Induction of colonic regulatory T cells by indigenous Clostridium species."
  Science, 331:337-41 (2011).
• 10.*Ivanov II, Atarashi K, Manel N, Brodie EL, Shima T, Karaoz U, Wei D, Goldfarb KC, Santee CA, Lynch SV, Tanoue T, Imaoka A, Itoh K, Takeda K, Umesaki Y, Honda K, Littman DR:
  "Induction of intestinal Th17 cells by segmented filamentous bacteria."
  Cell, 139:485-98 (2009).

Recent Research Results

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  Jan. 23, 2023
  Gut microbe degrades digestive enzyme trypsin in the large intestine

• 

  Feb. 19, 2016
  Good neighbors make good defenses

• 

  Sep. 27, 2013
  Intestinal bacteria show ‘community spirit’

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