Seed Compounds Exploratory Unit for Drug Discovery Platform

In this year, we set up HTS facilities, expanded a compound library for HTS, and completed HTS for 17 targets. The HTS campaign generated many primary hits, and promising candidates of hits were identified after the evaluation by secondary screenings.

Research Fields

Chemistry / Biology & Biochemistry / Molecular Biology & Genetics / Immunology / Microbiology

Research Subjects

• High throughput screening using in vitro and cell-based assay systems
• High content screening based on cell imaging
• High throughput screening for compounds that recover yeast phenotypes induced by human genes

Publications

1. Yashiroda, Y., Okamoto, R., Hatsugai, K., Takemoto, Y., Goshima, N., Saito, T., Hamamoto, M., Sugimoto, Y., Osada, H., Seimiya, H., and Yoshida, M.:
   "A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor."
   Biochem. Biophys. Res. Commun. 394, 569-573, (2010).