Chemical Bank Unit for Drug Discovery Platform

Our unit prepares chemical library for drug development, and provides them to the Seed Compounds Exploratory Unit for Drug Discovery Platform and other researchers in drug-discovery screening. We store the compounds, which are synthesized or purchased during exploration and optimization of drug seeds, and redistributes them for the purposes of validation of biological activity, toxicity or safety. We also develop cheminformatics modules quickly to select the compounds with chemical structure similar to hits, and to enhance of efficiency of compound provision.

Research Fields

Chemistry / Pharmacology & Toxicology / Clinical Medicine / Multidisciplinary

Research Subjects

• Storage of chemical libraries for drug-discovery
• Distribution of chemical libraries for HTS to explore drug seeds
• Utilization of cheminformatical modules to analyze chemical structures

Publications

1. Saito, T., Lepp, Z., Osada, H.:
   "Chemical screening database."
   THE LUNG perspectives, 17(3), 61-66 (2009)
2. Osada, H. and Hertwech, C.:
   "Exploring the chemical space of microbial natural products."
   Curr. Opn. Chem. Biol., 13, 133-134 (2009)