Chemical Resource Development Research Unit

Chemical library is one of the indispensable tools to promote the research on regulation of cell functions and drug-discovery with the strategy of chemical biology. To ensure utilization and application of the chemical library, we promote research supports in chemical biology and resource science by provision of chemical compounds, their information and structure-activity relationship analysis. Moreover we will enrich the chemical library by cooperation with Chemical Biology Research Group and Natural Product Biosynthesis Research Unit.

Research Fields

Chemistry / Biology & Biochemistry / Pharmacology & Toxicology / Agricultural Sciences / Environment & Ecology / Multidisciplinary

Research Subjects

• Utilization of chemical library
• Research promotion by structure-activity relationship analysis and optimization of chemical structures

Publications

1. Y. Noutoshi., M. Ikeda, T. Saito, H. Osada, K. Shirasu.:
   "Sulfonamides identified as plant immune-priming compounds in high-throughput chemical screening increase disease resistance in Arabidopsis thaliana"
   Front Plant Sci. 3, article 245, 1-10 (2012)
2. H. Kuniyoshi, I. Okumura, R. Kuroda, K. Arakawa, T. Saito, and H. Osada.:
   "Indomethacin induction of metamorphosis from the asexual stage to sexual stage in the moon jelly fish, Aurelia aurita"
   Biosci. Biotechnol. Biochem. 76, 1397-1400 (2012)
3. A. Yoneda, T. Ito, T. Higaki, N. Kutsuna, T. Saito, T. Ishimizu, H. Osada, S. Hasezawa, M. Matsui, T. Demura.:
   "Cobtorin target analysis reveals that pectin functions in deposition of cellulose microfibrils parallel to cortical microtubules in a manner dependent on the methylesterification ratio of pectin and its distribution"
   Plant J., 64, 657-667 (2010).
4. K. Tanaka, K. Nakamura, T. Saito, H. Osada, A. Hirai, H. Takahashi, S. Kanaya, Md.Altaf-Ul-Amin.:
   "Metabolic pathway prediction based on inclusive relation between cyclic substructures."
   Plant Biotechnology, 26, 459-468, 2009.