Cell Factory Research Team

Cost reduction of raw materials and processes is needed in order to use biomass as an alternative to fossil resources. Our team was established in April 2012 with an aim to integrating conventional processes, which are typically complicated and costly into a bio-process that is innovative, consistent, less costly and energy-saving. This will be achieved by optimizing, in an integrated manner, a plant's capacity to produce and degrade cellulose and the process of microorganisms' degrading and synthesizing biomass.

Research Fields

Engineering / Chemistry / Biology & Biochemistry / Computer Science

Research Subjects

• Develop a method for designing a microbial cell factory
• Building a cell factory
• Analysis of biomass

Publications

1. *Ismail, KSK., Sakamoto, T ., Hatanaka, H ., Hasunuma, T ., and Kondo, A .:
   "Gene expression cross-profiling in genetically modified industrial Saccharomyces cerevisiae strains during high-temperature ethanol production from xylose"
   J. Biotechnol. 163, 50-60 (2013).
2. Matsuda, F ., Kondo, T ., Ida, K ., Tezuka, H ., Ishii, J ., and Kondo, A .:
   "Construction of an Artificial Pathway for Isobutanol Biosynthesis in the Cytosol of Saccharomyces cerevisiae"
   Biosci. Biotechnol. Biochem. 76 , 2139-2141 (2012).
3. *Nishimura, Y ., Ishii, J ., Okazaki, F ., Ogino, C ., and Kondo, A.:
   "Complex carriers of affibody-displaying bio-nanocapsules and composition-varied liposomes for HER2-expressing breast cancer cell-specific protein delivery"
   J. Drug Targeting 20 , 897-905 (2012).
4. *Fukutani, Y ., Ishii, J ., Noguchi, K ., Kondo, A ., and Yohda, M .:
   "An improved bioluminescence-based signaling assay for odor sensing with a yeast expressing a chimeric olfactory receptor"
   Biotechnol. Bioeng. 109 , 3143-3151 (2012).
5. *Kiriyama, K ., Hara, KY ., and Kondo, A.:
   "Extracellular glutathione fermentation using engineered Saccharomyces cerevisiae expressing a novel glutathione exporter"
   Appl. Microbiol. Biotechnol. 96, 1021-1027 (2012).
6. Shirai, T., Matsuda, F., Okamoto, M., and Kondo, A.:
   "Evaluation of control mechanisms for Saccharomyces cerevisiae central metabolic reactions using metabolome data of eight single-gene deletion mutants"
   Appl. Microbiol. Biotechnol. [Epub ahead of print] (2012)