Regenerative Medicine Imaging Unit

Recent advancement in stem cell study such as ES cells and iPS cells has led to the expectation that regenerative therapy using ES cells, iPS cells or mesenchymal stem cells with transplantation for Parkinson's disease will be realized to replace lost dopaminergic neurons. However, little is known of the suitable differentiation state which keeps cells safest and produces large treatment effects for Parkinson's disease. We will establish molecular imaging techniques using MRI and PET to noninvasively verify the graft treatment.

Research Fields

Biology & Biochemistry / Pharmacology & Toxicology / Neuroscience & Behavior

Research Subjects

• Molecular imaging with non-human primates for regenerative medicine

Publications

1. Hayashi T, Wakao S, Kitada M, Ose T, Watabe H, Kuroda Y, Mitsunaga K, Matsuse D, Shigemoto T, Ito A, Ikeda H, Fukuyama H, Onoe H, Tabata Y, Dezawa M.:
   Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques.
   J Clin Invest. 123(1), 272-84 (2013).
2. * Doi D, Morizane A, Kikuchi T, Onoe H, Hayashi T, Kawasaki T, Motono M, Sasai Y, Saiki H, Gomi M, Yoshikawa T, Hayashi H, Shinoyama M, Mohamed R, Suemori H, Miyamoto S, Takahashi J.:
   Prolonged Maturation Culture Favors a Reduction in the Tumorigenicity and the Dopaminergic Function of Human ESC-Derived Neural Cells in a Primate Model of Parkinson's Disease.
   Stem Cells 30(5), 935-45 (2012).
3. * Kikuchi T, Morizane A, Doi D, Onoe H, Hayashi T, Kawasaki T, Saiki H, Miyamoto S, Takahashi J.:
   Survival of human induced pluripotent stem cell–derived midbrain dopaminergic neurons in the brain of a primate model of Parkinson's disease.
   Journal of Parkinson's Disease 1(4), 395-412 (2011).