Functional Architecture Imaging Unit

Using advanced dynamic imaging techniques, we will clarify the interconnections among organs or cells, which are involved in maintaining homeostasis in the body. We specially focus on the unique feature of nervous system—a network architecture and its activity that contribute to neural plasticity and regeneration. We also try to understand pathomechanism underlining central nervous system disorders, such as neurodegenerative disease and addiction.

Research Fields

Engineering / Clinical Medicine / Neuroscience & Behavior / Psychology & Psychiatry

Research Subjects

• Reorganization of brain network in plasticity after brain injury
• Regeneration of brain network after brain injury
• Transformation and control of brain network in brain disease

Publications

1. Hayashi, T., Ko, J.H., Strafella, A.P., Dagher, A.:
   "Dorsolateral prefrontal and orbitofrontal cortex interactions during self-control of cigarette craving."
   Proc. Natl. Acad. Sci. U.S.A. 110, 4422-4427 (2013)
2. Hayashi, T., Shimazawa, M., Watabe. H., Ose, T., Inokuchi, Y., Ito, Y., Yamanaka, H., Urayama, S., Watanabe, Y., Hara, H., Onoe, H.:
   "Kinetics of neurodegeneration based on a risk-related biomarker in animal model of glaucoma."
   Molecular Neurodegeneration. 8, 4 (2013)
3. Hayashi, T., Wakao, S., Kitada, M., Ose, T., Watabe, H., Kuroda, Y., Mitsunaga, K., Matsuse, D., Shigemoto, T., Ito, A., Ikeda, H., Fukuyama, H., Onoe, H., Tabata, Y., Dezawa, M.:
   "Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques."
   J. Clin. Invest. 23, 272–84 (2013)
4. Yokoyama, C., Kawasaki, A., Hayashi, T., Onoe, H.:
   "Linkage Between the Midline Cortical Serotonergic System and Social Behavior Traits: Positron Emission Tomography Studies of Common Marmosets."
   Cereb. Cortex July 12 (2012)
5. Shimazawa, M., Ito, Y., Inokuchi, Y., Yamanaka, H., Nakanishi, T., Hayashi, T., Ji, B., Higuchi, M., Suhara, T., Imamura, K., Araie, M., Watanabe, Y., Onoe, H., Hara, H. :
   "An alteration in the lateral geniculate nucleus of experimental glaucoma monkeys: in vivo positron emission tomography imaging of glial activation."
   PLoS ONE 7, e30526 (2012)
6. *Wakao, S., Hayashi, T., Kitada, M., Kohama, M., Matsue, D., Teramoto, N., Ose, T., Itokazu, Y., Koshino, K., Watabe, H., Iida, H., Takamoto, T., Tabata, Y., Dezawa, M.:
   "Long-term observation of auto-cell transplantation in non-human primate reveals safety and efficiency of bone marrow stromal cell-derived Schwann cells in peripheral nerve regeneration."
   Exp. Neurol. 223, 537–47 (2010)
7. *Ikoma, Y., Watabe, H., Hayashi, T., Miyake, Y., Teramoto, N., Minato, K., Iida, H.:
   "Measurement of density and affinity for dopamine D(2) receptors by a single positron emission tomography scan with multiple injections of [(11)C]raclopride."
   J. Cereb. Blood Flow Metab. 30, 663–73 (2010)
8. *Takagi, Y., Takahashi, J., Saiki, H., Morizane, A., Hayashi, T., Kishi, Y., Fukuda, H., Okamoto, Y., Koyanagi, M., Ideguchi, M., Hayashi, H., Imazato, T., Kawasaki, H., Suemori, H., Omachi, S., Iida, H., Itoh, N., Nakatsuji, N., Sasai, Y., Hashimoto, N. :
   "Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model."
   J Clin Invest. 115, 102–9 (2005)
9. *Hayashi, T., Ohnishi, T., Okabe, S., Teramoto, N., Nonaka, Y., Watabe, H., Imabayashi, E., Ohta, Y., Jino, H., Ejima, N., Sawada, T., Iida, H., Matsuda, H., Ugawa, Y. :
   "Long-term effect of motor cortical repetitive transcranial magnetic stimulation."
   Ann Neurol. 56, 77–85 (2004)
10. *Hayashi, T., Watabe, H., Kudomi, N., Kim, K.M., Enmi, J., Hayashida, K., Iida, H. :
    "A theoretical model of oxygen delivery and metabolism for physiologic interpretation of quantitative cerebral blood flow and metabolic rate of oxygen."
    J Cereb Blood Flow Metab. 23, 1314–23 (2003)