Cellular Function Imaging Team

We are investigating physiological or pathological roles of cells functioning in living tissues by using in vivo imaging methods including PET, MRI, and optical imaging. In particular, we aim to establish new strategies for treating neurological disorders or malignancy by imaging stem/progenitor cells in the central nervous system or cancer/cancer stem cells. Further, we study metabolic dynamics in pathophysiological states including fatigue, and develop new techniques for controlling the living systems.

Research Fields

Biology & Biochemistry / Immunology / Neuroscience & Behavior / Psychology & Psychiatry

Research Subjects

• Imaging and functional analysis of stem/progenitor cells in vivo
• Analysis and control of metabolic dynamics in pathophysiological states including fatigue
• Development of novel multimodal imaging techniques and photo-dynamic techniques for manipulating cellular function in vivo

Publications

1. *Toba, S., Tamura, Y., Kumamoto, K., Yamada, M., Takao, K., Hattori, S., Miyakawa, T., Kataoka, Y., Azuma, M., Hayasaka, K., Amamoto, M., Tominaga, K., Wynshaw-Boris, A., Wanibuchi, H., Oka, Y., Sato, M., Kato, M., and Hirotsune, S.:
   "Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly"
   Sci. Rep. 3: 1224 (2003)
2. *Cui, Y., Li, QH., Yamada H., Watanabe, Y., and Kataoka, Y.:
   "Chronic degeneration of dorsal raphe serotonergic neurons modulates cortical spreading depression: A possible pathophysiology of migraine"
   J. Neurosci. Res. in press
3. *Yamato, M., Kaneda, A., and Kataoka, Y.:
   "Low-reactive level laser irradiation improves crescentic glomerulonephritis in rats"
   Lasers Med. Sci. in press
4. *Tamura, Y., Eguchi, A., Jin, G., Sami, M., and Kataoka, Y.:
   "Cortical spreading depression shifts cell fate determination of progenitor cells in the adult cortex"
   J. Cereb. Blood Flow Metab. 32: 1879-1887 (2012)
5. *Ozawa, M., Takahashi, K., Akazawa, K., Takashima, T., Nagata, H., Doi, H., Hosoya, T., Wada, Y., Cui, Y., Kataoka, Y., and Watanabe, Y.:
   "PET of aromatase in gastric parietal cells using 11C-vorozole"
   J. Nucl. Med. 52: 1964-1969 (2011)
6. *Cui, Y., Takashima, T., Takashima-Hirano, M., Wada, Y., Shukuri, M., Tamura, Y., Doi, H., Onoe, H., Kataoka, Y., and Watanabe, Y.:
   "¹¹C-PK11195 PET for the in vivo evaluation of neuroinflammation in the rat brain after cortical spreading depression"
   J. Nucl. Med. 50: 1904-1911 (2009)
7. *Yamato, M., Kataoka, Y., Mizuma, H., Wada, Y., and Watanabe, Y.:
   "Positron emission tomography and macro- and micro-autoradiographic studies combined with immunohistochemistry on rat intestinal ulceration and healing processes"
   J. Nucl. Med. 50, 1-8 (2009)
8. *Cui, Y., Kataoka, Y., Inui, T., Mochizuki, T., Onoe, H., Matsumura, K., Urade, Y., Yamada, H., and Watanabe, Y.:
   "Upregulated neuronal COX-2 expression after cortical spreading depression is involved in non-REM sleep induction in rats"
   J. Neurosci. Res. 86, 929-936 (2008)
9. *Tamura, Y., Kataoka, Y., Cui, Y., Takamori, Y., Watanabe, Y., and Yamada, H.:
   "Intracellular translocation of glutathione S-transferase pi during oligodendrocyte differentiation in the adult rat cerebral cortex in vivo"
   Neuroscience 148, 535-540 (2007)
10. *Tamura, Y., Kataoka, Y., Cui, Y., Takamori, Y., Watanabe, Y., and Yamada, H.:
    "Multi-directional differentiation of doublecortin- and NG2-immunopositive progenitor cells in the adult rat neocortex in vivo"
    Eur. J. Neurosci. 25, 3489-3498 (2007)