Bio-function Imaging Team

For integrative understanding of the biological phenomena in life, we develop the method of dynamic imaging for complex biological and cellular functions under living state in the normal and disease-model animals of various species, including primates. In addition, we develop the novel molecular imaging probes, which are required for drug development work together cooperatively with the Labelling Chemistry Team.

Research Fields

Biology & Biochemistry / Pharmacology & Toxicology / Neuroscience & Behavior

Research Subjects

• Development of new-generation original PET radiotracers
• Development of molecular imaging techniques for monitoring biological events

Publications

1. Mizuma H, Shukuri M, Hayashi T, Watanabe Y, Onoe H.:
   Establishment of in vivo brain imaging method in conscious mice.
   J Nucl Med 51(7), 1068-1075 (2010).
2. Kawasaki T, Ago Y, Yano K, Araki R, Washida Y, Onoe H, Chaki S, Nakazato A, Hashimoto H, Baba A, Takuma K, Matsuda T.:
   Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in isolation-reared mice.
   Neuropharmacology 60(2-3), 397-404 (2011).
3. * Kambe T, Motoi Y, Inoue R, Kojima N, Tada N, Kimura T, Sahara N, Yamashita S, Mizoroki T, Takashima A, Shimada K, Ishiguro K, Mizuma H, Onoe H, Mizuno Y, Hattori N.:
   Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice.
   Neurobiol Dis 42(3), 404-14 (2011).
4. Takashima T, Yokoyama C, Mizuma H, Yamanaka H, Wada Y, Onoe K, Nagata H, Tazawa S, Doi H, Takahashi K, Morita M, Kanai M, Shibasaki M, Kusuhara H, Sugiyama Y, Onoe H, Watanabe Y.:
   Developmental Changes in P-glycoprotein Function in the Blood-Brain Barrier of Non-Human Primates: PET Study with R-11C-Verapamil and [11C]Oseltamivir.
   J Nucl Med 52(6), 950-7 (2011).
5. Shukuri M, Takashima-Hirano M, Tokuda K, Takashima T, Matsumura K, Inoue O, Doi H, Suzuki M, Watanabe Y, Onoe H.:
   In vivo expression of cyclooxygenase-1 in activated microglia/macrophages during neuroinflammation visualized by PET with 11C-Ketoprofen-methyl ester.
   J Nucl Med 52(7), 1094-101 (2011).
6. * Nishimura Y, Onoe H, Onoe K, Morichika Y, Tsukada H, Isa T.:
   Neural substrates for the motivational regulation of motor recovery after spinal-cord injury.
   PLoS ONE 6(9), e24854 (2011).
7. * Shimazawa M, Ito Y, Inokuchi Y, Yamanaka H, Nakanishi T, Hayashi T, Ji B, Higuchi M, Suhara T, Imamura K, Araie M, Watanabe Y, Onoe H, Hara H.:
   An Alteration in the Lateral Geniculate Nucleus of Experimental Glaucoma Monkeys: In vivo Positron Emission Tomography Imaging of Glial Activation.
   PLoS One 7(1), e30526 (2012).
8. Yokoyama C, Kawasaki A, Hayashi T, Onoe H.:
   Linkage Between the Midline Cortical Serotonergic System and Social Behavior Traits: Positron Emission Tomography Studies of Common Marmosets.
   Cereb Cortex (in press) (2012).
9. * Nakazawa S, Yokoyama C, Nishimura N, Horisawa T, Kawasaki A, Mizuma H, Doi H, Onoe H.:
   Evaluation of dopamine D(2)/D (3) and serotonin 5-HT (2A) receptor occupancy for a novel antipsychotic, lurasidone, in conscious common marmosets using small-animal positron emission tomography.
   Psychopharmacology (Berl) 225(2), 329-39 (2013).
10. * Yeh HH, Tian M, Hinz R, Young D, Shavrin A, Mukhapadhyay U, Flores LG, Balatoni J, Soghomonyan S, Jeong HJ, Pal A, Uthamanthil R, Jackson JN, Nishii R, Mizuma H, Onoe H, Kagawa S, Higashi T, Fukumitsu N, Alauddin M, Tong W, Herholz K, Gelovani JG.:
    Imaging epigenetic regulation by histone deacetylases in the brain using PET/MRI with (18)F-FAHA.
    Neuroimage 64, 630-9 (2013).