Pathophysiological and Health Science Team

Research Fields

Chemistry / Materials Sciences / Biology & Biochemistry / Molecular Biology & Genetics / Immunology / Pharmacology & Toxicology / Clinical Medicine / Agricultural Sciences / Plant & Animal Science / Microbiology / Neuroscience & Behavior / Computer Science / Psychology & Psychiatry / Social Sciences & General / Environment & Ecology / Multidisciplinary

Research Subjects

• Molecular imaging study on newly developed biomarkers for evaluation of health and pre-disease state
• Molecular imaging study on newly developed biomarkers for evaluation of disease state
• Development of molecular imaging indices for products to avoid deterioration of health

Publications

1. Yamashita, S., Takashima, T., Kataoka, M., Oh, H., Sakuma, S., Takahashi, M., Suzuki, N., Hayashinaka, E., Wada, Y., Cui, Y., and Watanabe, Y.:
   "PET Imaging of the Gastrointestinal Absorption of Orally Administered Drugs in Conscious and Anesthetized Rats."
   J. Nucl. Med. 52(2) 249-56 (2011).
2. Takashima, T., Yokoyama, C., Mizuma, H., Yamanaka, H., Wada, Y., Onoe, K., Nagata, H., Tazawa, S., Doi, H., Takahashi, K., Morita, M., Kanai, M., Shibasaki, M., Kusuhara, H., Sugiyama, Y., Onoe, H., and Watanabe, Y.:
   "Developmental Changes in P-glycoprotein Function in the Blood-Brain Barrier of Non-Human Primates: PET Study with R-[11C] Verapamil and [11C] Oseltamivir."
   J. Nucl. Med. 52(6) 950-957 (2011).
3. Shukuri, M., Takashima-Hirano, M., Tokuda, K., Takashima, T., Matsumura, K., Inoue, O., Doi, H., Suzuki, M., Watanabe, Y., and Onoe, H.:
   "In vivo expression of cyclooxygenase-1 in activated microglia/macrophages during neuroinflammation visualized by PET with 11C-Ketoprofen-methyl ester."
   J. Nucl. Med. 52(7) 1094-1101 (2011).
4. Takashima, T., Hashizume, Y., Katayama, Y., Murai, M., Wada, Y., Maeda, K., Sugiyama, Y., and Watanabe, Y.:
   "The involvement of organic anion transporting polypeptide in the hepatic uptake of telmisartan in rats: PET studies with 11C telmisartan."
   Mol. Pharm. 8(5) 1789-1798 (2011).
5. Ozawa, M., Takahashi, K., Akazawa, K., Takashima, T., Nagata, H., Doi, H., Hosoya, T., Wada, Y., Cui, Y.L., Kataoka, Y., and Watanabe, Y.:
   "Positron emission tomography imaging of aromatase in gastric parietal cells using [11C]Vorozole."
   J. Nucl. Med. 52(12) 1964-1969 (2011).
6. Shingaki, T., Takashima, T., Wada, Y., Tanaka, M., Kataoka, M., Ishii, A., Shigihara, Y., Sugiyama, Y., Yamashita, S., and Watanabe, Y.:
   "Imaging of gastrointestinal absorption and biodistribution of orally administered probe of positron emission tomography in human."
   Clin. Pharmacol. Ther. 91(4) 653-659 (2012).
7. Yamamoto, S., Ouchi, Y., Nakatsuka, D., Tahara, T., Mizuno, K., Tajima, S., Onoe, H., Yoshikawa, E., Tsukada, H., Iwase, M., Yamaguti, K., Kuratsune, H., and Watanabe, Y.:
   "Reduction of 11C-(+)3-MPB binding in brain of chronic fatigue syndrome with serum autoantibody against muscarinic cholinergic receptor."
   PLoS One 7(12) e51515 (2012).
8. Takashima, T., Wu, C., Takashima-Hirano, M., Katayama, Y., Wada, Y., Suzuki, M., Kusuhara, H., Sugiyama, Y., and Watanabe, Y.:
   "Evaluation of breast cancer resistance protein function in hepatobiliary and renal excretion using PET with [11C]SC-62807."
   J. Nucl. Med. 54(2) 183-186 (2012).
9. Nakamura, I., Hasegawa, K., Wada, Y., Hirase, T., Node, K., and Watanabe, Y.:
   "Detection of early stage atherosclerotic plaques using PET and CT fusion
   imaging targeting P-selectin in low density lipoprotein receptor-deficient mice."
   Biochem. Biophys. Res. Commun. in press (2013).
10. Mizuno, K., Yoneda, T., Komi, M., Hirai, T., Watanabe, Y., and Tomoda, A.:
    "Osmotic release oral system-methylphenidate improves neural activity during low reward processing in children and adolescents with attention-deficit/hyperactivity disorder." Neuroimage:Clinical in press (2013).