Next-generation Imaging Team

For the advancement of Bio-function Dynamics Imaging, our mission is to develop next-generation molecular imaging technologies such as the simultaneous multiple-molecular imaging, multi-modal fusion molecular imaging which integrates morphology and physiology, and especially highlighted technology of the GREI (Gamma-Ray Emission Imaging) apparatus. In addition, we will pursue the possibility of the multiple-molecular imaging with PET nuclides.

Research Fields

Physics / Engineering / Chemistry / Materials Sciences / Biology & Biochemistry / Molecular Biology & Genetics / Immunology / Pharmacology & Toxicology / Clinical Medicine / Agricultural Sciences / Plant & Animal Science / Microbiology / Neuroscience & Behavior / Computer Science / Environment & Ecology / Multidisciplinary / Space Science / Geosciences

Research Subjects

• Development of the multiple-molecular imaging apparatus and its application
• R&D of the multiple-molecular imaging technology with PET nuclides
• Fusion of molecular imaging science and metallomics research

Publications

1. Taniguchi M, Fukunaka A, Hagihara M, Watanabe K, Kamino S, Kambe T, Enomoto S, and Hiromura M.:
   "Essential role of the zinc transporter ZIP9/SLC39A9 in regulating the activations of Akt and Erk in B-cell receptor signaling pathway in DT40 cells,"
   PLOS ONE, in press (2013)
2. Kamino S, Muranaka A, Murakami M, Tatsumi A, Nagaoka N, Shirasaki Y, Watanabe K, Yoshida K, Horigome J, Komeda S, Uchiyama M, and Enomoto S:
   "A Red-Emissive Aminobenzopyrano-xanthene Dye: Elucidation of Fluorescence Emission Mechanism in Solution and Aggregate State,"
   Phys. Chem. Chem. Phys., 15, 2131-2140 (2013)
3. Takeda S, Odaka H, Ishikawa S, Watanabe S, Aono H, Takahashi T, Kanayama Y, Hiromura M, and Enomoto S:
   "Demonstration of in-vivo multi-probe tracker based on a Si/CdTe semiconductor Compton camera,"
   IEEE Trans. Nucl. Sci., 59, 70-76 (2012).
4. Fukuchi T, Arai Y, Watanabe F, Motomura S, Takeda S, Kanayama Y, Haba H, Watanabe Y, and Enomoto S:
   "A Digital Signal Processing Module for Ge Semiconductor Detectors,"
   IEEE Trans. Nucl. Sci., 58, 461-467 (2011)
5. Kamino S, Horio Y, Komeda S, Minoura K, Ichikawa H, Horigome J, Tatsumi A, Kaji S, Yamaguchi T, Usami Y, Hirota S, Enomoto S, and Fujita Y:
   "A new class of rhodamine luminophores: design, syntheses and aggregation-induced emission enhancement,"
   Chem. Commun., 46(47): 9013-9015 (2010)
6. Motomura S, Kanayama Y, Haba H, Watanabe Y, and Enomoto S:
   "Multiple molecular simultaneous imaging in a live mouse using semiconductor Compton camera,"
   J. Anal. At. Spectrom., 23, 1089-1092 (2008)
7. Motomura S, Enomoto S, Haba H, Igarashi K, Gono Y, and Yano Y:
   "Gamma-ray Compton imaging of multitracer in biological samples using strip germanium telescope,"
   IEEE Transaction on Nuclear Science, 54, 710-717 (2007)
8. Enomoto S and Motomura S:
   "Development of the multiple nuclides simultaneous imaging by using Ge Compton telescope,"
   Isotope News, 4, 2-5, (2006)
9. Haba H, Kaji D, Kanayama Y, Igarashi K, Enomoto S:
   "Development of a gas-jet multitarget system for multitracer production,"
   Radiochim. Acta, 93, 539-542 (2005)
10. Enomoto S:
    "Development of Multitracer Technology and Application Studies on Biotrace Element Research,"
    Biomed. Res. Trace Elem., 16, 233-240 (2005)