Nano Medical Engineering Laboratory

This laboratory aims to create new functional materials by a new method which will be developed by combination of chemical and biotechnological methodology. We use organic synthetic chemistry, combinatorial chemistry, molecular engineering, polymer engineering, hybrid materials engineering, gene and protein engineering, microfabrication technology, and nanotechnology to synthesize new materials and the systems for development of regenerative medicine, artificial organs, drug delivery systems, nanomedicine, molecular imaging, biochips, bioelectronics, artificial enzymes and artificial antibodies.

Research Subjects

• Biomaterials for regenerative medicine
• Nanomedicine using RNAi
• Development of microarray biochips
• Development of molecular probes for cellular imaging
• Development of high perfromance organic catalyst by combinatorial engineering

Publications

1. Aya Shibata, Yoshihiro Ito, Hiroshi Abe:
   "RNA-templated molecule release induced protein expression in bacterial cells"
   Chem. Commun., 49, 270-272 (2013)
2. Zha Li, Takanori Uzawa, Takashi Tanaka, Akira Hida, Koji Ishibashi, Hiromichi Katakura, Eiry Kobatake, and Yoshihiro Ito:
   "In vitro selection of peptide aptamers with affinity to single-wall carbon nanotubes using a ribosome display"
   Biotechnol. Lett., 35(1), 39-45 (2013)
3. Mingzhe Liu, Seiichi Tada, Mika Ito, Hiroshi Abe, and Yoshihiro Ito:
   "In vitro selection of a photo-responsive peptide aptamer by ribosome display"
   Chem. Commun., 48, 11871-11873 (2012)
4. Seiichi Tada, Takashi Andou, Takehiro Suzuki, Naoshi Dohmae, Eiry Kobatake, and Yoshihiro Ito
   "Genetic PEGylation"
   PLoS ONE, e49235 (2012)
5. Hiroshi Abe, Naoko Abe, Aya Shibata, Keiji Ito, Yoshiyuki Tanaka, Mika Ito, Hisao Saneyoshi, Satoshi Shuto, and Yoshihiro Ito:
   "Structure formation and catalytic activity of DNA in organic solvents"
   Angew. Chem. Int. Ed., 51, 6475-6479, (2012)
6. Hongxu Lu, Naoki Kawazoe, Takashi Kitajima, Yuka Myoken, Masahiro Tomita, Akihiro Umezawa, Guoping Chen, and Yoshihiro Ito:
   "Spatial immobilization of bone morphogenetic protein-4 in a collagen-PLGA hybrid scaffold for enhanced osteoinductivity"
   Biomaterials, 33, 6140-6146 (2012)
7. Xiao-Shan Yue, Masako Fujishiro, Chieko Nishioka, Takashi Arai, Eiki Takahashi, Jian-Sheng Gong, Toshihiro Akaike, and Yoshihiro Ito:
   "Feeder cells support the culture of induced pluripotent stem cells even after chemical fixation"
   PLoS ONE, 7(3), e32707 (2012)
8. Jeonghwa Kang, Makoto Sakuragi, Aya Shibata, Hiroshi Abe, Takashi Kitajima, Seiichi Tada, Masayoshi Mizutani, Hitoshi Ohmori, Hiroto Ayame, Tae Il Son, Toshiro Aigaki, and Yoshihiro Ito:
   "Immobilization of epidermal growth factor on titanium and stainless steel surfaces via dopamine treatment"
   Mater. Sci. Eng. C, 32, 2552-2561 (2012)
9. Mika Ito, Aya Shibata, Jie Zhang, Michio Hiroshima, Yasushi Sako, Yukiko Nakano, Kyoko Kojima-Aikawa, Bengt Mannervik, Satoshi Shuto, Yoshihiro Ito, Ralf Morgenstern, Hiroshi Abe:
   "Universal caging group for in cell detection of glutathione transferase applied to 19F NMR and bioluminogenic probes"
   ChemBioChem, 13, 1428-1432 (2012)
10. Yoshihiro Ito, Nozomi Moritsugu, Takahisa Matsue, Kiyomi Mitsukoshi, Hiroto Ayame, Norihiro Ookouchi, Hideshi Hattori, Hideo Tashiro, Sakura Sato, and Motohiro Ebisawa:
    "An automated multiplex specific IgE assay system using a photoimmobilized microarray"
    J. Biotechnol., 161, 414-421 (2012)