Laboratory for Reconstitutive Developmental Biology

Our research interests are in cell-cell communications that occur during development of multicellular organisms. The cells communicate with each other to autonomously differentiate into different cell types and to form spatial patterns in a variety of tissues. To understand the mechanisms, we have been reconstituting the cell-cell communications by constructing artificial gene networks in cultured cells.

Research Fields

Physics / Engineering / Biology & Biochemistry / Molecular Biology & Genetics / Multidisciplinary

Research Subjects

• Reconstitution of cell autonomous differentiation
• Reconstitution of cell pattern formation

Publications

1. * Uno M, Honjoh S, Matsuda M, Hoshikawa H, Kishimoto S, Yamamoto T, Ebisuya M, Yamamoto T, Matsumoto K and Nishida E.
   A fasting-responsive signaling pathway that extends life span in C. elegans.
   Cell Rep., 3, 79-91 (2013).
2. * Tanimura N, Saito M, Ebisuya M, Nishida E and Ishikawa F.
   Stemness-related Factor Sall4 Interacts with Transcription Factors Oct-3/4 and Sox2 and Occupies Oct-Sox Elements in Mouse Embryonic Stem Cells.
   J. Biol. Chem., 288, 5027-5038 (2013).
3. * Matsuda M, Koga M, Nishida E and Ebisuya M.
   Synthetic Signal Propagation Through Direct Cell-Cell Interaction.
   Sci. Signal., 5, ra31 (2012).
4. * Matsumura S, Hamasaki M, Yamamoto T, Ebisuya M, Sato M, Nishida E and Toyoshima F.
   ABL1 regulates spindle orientation in adherent cells and mammalian skin.
   Nat. Commun., 3, doi: 10.1038/ncomms1634 (2012).
5. * Sunadome K, Yamamoto T, Ebisuya M, Kondoh K, Sehara-Fujisawa A and Nishida E.
   ERK5 regulates muscle cell fusion through Klf transcription factors.
   Dev. Cell, 20, 192-205 (2011).
6. * Mitsushima M, Aoki K, Ebisuya M, Matsumura S, Yamamoto T, Matsuda M, Toyoshima F and Nishida E.
   Revolving movement of a dynamic cluster of actin filaments during mitosis.
   J. Cell Biol., 191, 453-462 (2010).
7. * Yamazaki T, Fujiwara N, Yukinaga H, Ebisuya M, Shiki T, Kurihara T, Kioka N, Kambe T, Nagao M, Nishida E and Masuda S.
   The closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progression.
   Mol. Biol. Cell, 21, 2953-2965 (2010).
8. * Ebisuya M, Yamamoto T, Nakajima M and Nishida E.
   Ripples from neighbouring transcription.
   Nat. Cell Biol., 10, 1106-1113 (2008).
9. * Yamamoto T*, Ebisuya M* (*Equal first authors), Ashida F, Okamoto K, Yonehara S and Nishida E.
   Continuous ERK activation downregulates antiproliferative genes throughout G1 phase to allow cell-cycle progression.
   Curr. Biol., 16, 1171-1182 (2006).
10. * Matsubayashi Y, Ebisuya M, Honjoh S and Nishida, E.
    ERK activation propagates in epithelial cell sheets and regulates their migration during wound healing.
    Curr. Biol., 14, 731-735 (2004).