多方向かつ段階的に進行する細胞分化における運命決定メカニズムの解明究領域略称:細胞運命制御

主な業績

2012年度 - 原著論文

* correspondence

Ge WP, Miyawaki A, Gage FH, Jan YN, *Jan LY.
Local generation of glia is a major astrocyte source in postnatal cortex.
Nature. 484: 376-380. 2012.

Mitsuishi Y, Taguchi K, Kawatani Y, Shibata T, Nukiwa T, Aburatani H, *Yamamoto M, *Motohashi H.
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.
Cancer Cell. 22(1): 66-79. 2012.

Suzuki S, Iwamoto M, Saito Y, Fuchimoto D, Sembon S, Suzuki M, Mikawa S, Hashimoto M, Aoki Y, Najima Y, Takagi S, Suzuki N, Suzuki E, Kubo M, Mimuro J, Kashiwakura Y, Madoiwa S, Sakata Y, Perry AC, Ishikawa F, *Onishi A.
Il2rg gene-targeted severe combined immunodeficiency pigs.
Cell Stem Cell. 10: 753-758. 2012.

*Nagao K, Kobayashi T, Moro K, Ohyama M, Adachi T, Kitashima DY, Ueha S, Horiuchi K, Tanizaki H, Kabashima K, Kubo A, Cho YH, Clausen BE, Matsushima K, Suematsu M, Furtado GC, Lira SA, Farber JM, Udey MC, Amagai M.
Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin.
Nat Immunol. 13: 744-752. 2012.

Nishio M, Hamada K, Kawahara K, Sasaki M, Noguchi F, Chiba S, Mizuno K, Suzuki SO, Dong Y, Tokuda M, Morikawa M, Hikasa H, Eggenschwiler J, Yabuta N, Nojima H, Nakagawa K, Hata Y, Nishina H, Mimori K, Mori M, Sasaki T, Mak TW, Nakano T, Itami S, *Suzuki A.
Cancer Susceptibility and embryonic lethality in Mob1A/1B double mutant mice.
J Clin Invest. 122(12):4505-4518.2012.

Hoshii T, Tadokoro Y, Naka K, Ooshio T, Muraguchi T, Sugiyama N, Soga T, Araki K, Yamamura K, Hirao A*.
mTORC1 is essential for leukemia-propagation but not stem cell self-renewal.
J Clin Invest. 122(6):2114-29. 2012.

Lim KC, Hosoya T, Brandt W, Ku CJ, Hosoya-Ohmura S, Camper SA, Yamamoto M, *Engel JD.
Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning.
J Clin Invest.122(10):3705-17.2012.

Kurebayashi Y, Nagai S, Ikejiri A, Ohtani M, Ichiyama K, Baba Y, Yamada T, Egami S, Hoshii T, Hirao A, Matsuda S, Koyasu S*.
PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi-1 expression and nuclear translocation of ROR<gamma>
Cell Reports. 1(4):360-373. 2012.

Yu M, Mazor T, Huang H, Huang HT, Kathrein KL, Woo AJ, Chouinard CR, Labadorf A, Akie TE, Moran TB, Xie H, Zacharek S, Taniuchi I, Roeder RG, Kim CF, Zon LI, Fraenkel E, *Cantor AB.
Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.
Mol Cell. 45:330-43. 2012.

Ozaki Y, Matsui H, Asou H, Nagamachi A, Aki D, Honda H, Yasunaga S, Takihara Y, Yamamoto T, Izumi S, Ohsugi M, Inaba T.
Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation.
Mol. Cell. 47: 694-706, 2012

Oguro H, Yuan J, Tanaka S, Miyagi S, Mochizuki-Kashio M, Ichikawa H, Yamazaki S, Koseki H,
Nakauchi H, Iwama A.
Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes.
J Exp Med. 209:445-454, 2012.

Seo W, Kawamoto H, *Taniuchi I.
Runx1-Cbfβ facilitates early B lymphocyte development by regulating expression of Ebf1.
J Exp Med. 209: 1255-1262. 2012.

Wang L, Tsutsumi S, Kawaguchi T, Nagasaki K, Tatsuno K, Yamamoto S, Sang F, Sonoda K, Sugawara M, Saiura A, Hirono S, Yamaue H, Miki Y, Isomura M, Totoki Y, Nagae G, Isagawa T, Ueda H, Murayama-Hosokawa S, Shibata T, Sakamoto H, Kanai Y, Kaneda A, Noda T, Aburatani H.
Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency.
Genome Research. 22(2): 208-19. 2012

*Watarai H, Sekine-Kondo E, Shigeura T, Motomura Y, Yasuda T, Satoh R, Yoshida H, Kubo M, Kawamoto H, Koseki H, Taniguchi M.
Development and function of invariant natural killer T cells producing th2- and th17-cytokines.
PLOS Biology. 10: e1001255, 2012.

Hasegawa A, *Shimizu R, Mohandas N, *Yamamoto M.
Mature erythrocyte membrane homeostasis is compromised by loss of the GATA1-FOG1 interaction.
Blood. 119(11):2615-23.2012.

Kumano K, Arai S, Hosoi M, Taoka K, Takayama N, Otsu M, Nagae G, Ueda K, Nakazaki K, Kamikubo Y, Eto K, Aburatani H, Nakauchi H, *Kurokawa M.
Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples.
Blood. 119(26): 6234-42. 2012.

Kawamata T, Lu J, Sato T, Tanaka M, Nagaoka H, Agata Y, Toyoshima T, Yokoyama K, Oyaizu N, Nakamura N, Ando K, *Tojo A, *Kotani A. 
Imatinib mesylate directly impairs class switch recombination through downregulation of AID. 
Blood. 119: 3123-3127, 2012.

Takase H, Matsumoto K, Yamadera R, Kubota Y, Otsu A, Suzuki R, Ishitobi H, Mochizuki H, Kojima T, Takano S, Uchida K, Takahashi S, *Ema M.
Genome-wide identification of endothelial cell-enriched genes in the mouse embryo.
Blood. 120: 914-923. 2012.

Kawai T, *Nishikomori R. Izawa K, Murata Y, Tanaka N, Sakai H, Saito M, Yasumi T, Takaoka Y, Nakahata T, Mizukami T, Nunoi H, Kiyohara Y, Yoden A, Murata T, Sasaki S, Ito E, Akutagawa H, Kawai T, Imai C, Okada S,Kobayashi M, Heike T.
Frequent somatic mosaicism of NEMO in T cells of patients with X-1 linked anhidrotic ectodermal dysplasia with immunodeficiency.
Blood. 119:5458-5466. 2012.

Isoda T, *Takagi M, Piao J, Nakagama S, Sato M, Masuda K, Ikawa T, Azuma M, Morio T,
Kawamoto H, *Mizutani S.
Process for immune defect and chromosomal translocation during early thymocyte development lacking ATM.
Blood. 120: 789-799. 2012.

Tanaka S, Miyagi S, Sashida G, Chiba T, Yuan J, Mochizuki-Kashio M, Suzuki Y, Sugano S, Nakaseko C, Yokote K, Koseki H,Iwama A.
Ezh2 augments leukemogenecity by reinforcing differentiation blockage in acute myeloid leukemia.
Blood. 120:1107-1117, 2012.

Yokoyama T, Toki T, Aoki Y,Park MJ, Kanno Y, Tanaka T, Yamazaki Y, Ito E, Hayashi Y, *Nakamura T.
Identification of TRIB1 R107L gain-of-function mutation in human acute megakaryocytic leukemia.
Blood. 119: 2608-2611. 2012.

Takagi S, Saito Y, Hijikata A, Tanaka S, Watanabe T, Hasegawa T, Mochizuki S, Kunisawa J, Kiyono H, Koseki H, Ohara O, Saito T, Taniguchi S, Shultz LD, Ishikawa F.
Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation.
Blood. 119: 2768-2777. 2012.

Kuramitsu M, Sato-Otsubo A, Morio T, Takagi M, Toki T, Terui K, Wang RN, Kanno H, Ohga S, Ohara A, Kojima S, Kitoh T, Goi K, Kudo K, Matsubayashi T, Mizue N, Ozeki M, Masumi A, Momose H, Takizawa K, Mizukami T, Yamaguchi K, Ogawa S, *Ito E, *Hamaguchi I. Extensive gene deletions in Japanese patients with Diamond_Blackfan anemia.
Blood. 119: 2376-2384. 2012.

Miyaoka Y, Ebato K, Kato H, Arakawa S, Shimizu S, and *Miyajima A.
Hypertrophy and unconventional cell division of hepatocytes underlie liver regeneration.
Current Biology.  22: 1166-1175, 2012.

Hirose Y, Saijou E, Sugano Y, Takeshita F, Nishimura S, Nonaka H, Chen Y-R, Sekine K, Kido T, Nakamura T, Kato S, Kanke T, Nakamura K, Nagai R, Ochiya T and *Miyajima A.
Inhibition of Stabilin-2 elevates the circulating hyaluronic acid level and prevents tumor metastasis. 
Proc. Natl. Acad. Sci. USA. 109: 4263-4268, 2012.

Koso H, Takeda H, Yew C, Ward JM, Nariai N, Ueno K, Nagasaki M,Watanabe S, Rust AG, Adams DJ, Copeland NG, Jenkins NA
Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cells,
Proc. Natl. Acad. Sci. USA. 109(44):E2998-3007. 2012

Kawamura S, Sato I, Wada T, Yamaguchi K, Li Y, Li D, Zhao X, Ueno S, Aoki H, Tochigi T, Kuwahara M,Kitamura T, Takahashi K, Moriya S, Miyagi T.
Plasma membrane-associated sialidase (NEU3) regulates progression of prostate cancer to androgen-independent growth through modulation of androgen receptor signaling.
Cell Death and Differentiation. 19: 170-179. 2012.

Kondo Y, Iizuka M, Wakamatsu E, Yao Z, Tahara M, Tsuboi H, Sugihara M, Hayashi T, Yoh K,Takahashi S,Matsumoto I, *Sumida T.
Overexpression of T-bet gene regulates murine autoimmune arthritis.
Arthritis Rheum. 64: 162-172, 2012.

Inoue A, *Matsumoto I, Tanaka Y, Umeda N, Tanaka Y, Mihara M, Takahashi S, Sumida T.
TIARP (TNFAIP9) deficiency leads to arthritis via IL-6 overproduction with enhanced NF-κB, STAT3 signaling and dysregulated apoptosis of macrophages.
Arthritis Rheum. 64(12):3877-85.2012

Zhang X, *Inukai T, Hirose K, Akahane K, Kuroda I, Honna-Oshiro H, Kagami K,  Goi K, Nakamura K,  Kobayashi M, Endo M, Yagita H, Kurosawa H, Look AT, Honda H, Inaba TNakazawa S, Sugita K.
Oncogenic Fusion E2A-HLF Sensitizes t(17;19)-positive Acute Lymphoblastic Leukemia to TRAIL-Mediated Apoptosis by Upregulating the Expression of Death Receptors.
Leukemia. 26(12):2483-93. 2012.

Ueda T, Sanada M, Matsui H, Yamasaki N, Honda Zi, Shih LY, Mori H, Inaba T,Ogawa S, and *Honda H. EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome and related neoplasms.
Leukemia. 26(12):2557-60.2012.

* Mihara K, Bhattacharyya J, Kitanaka A, Yanagihara K, Kubo T, Takei Y, Sakai A, Asaoku H,Takihara Y, Kimura A.
T-cell immunotherapy with a chimeric receptor against CD38 is effective in eliminating myeloma cells. 
Leukemia. 26: 365-367. 2012.

Shide K, Kameda T, Shimoda H, Yamaji T, Abe H, Kamiunten A, Sekine M, Hidaka T, Katayose K, Kubuki Y, Yamamoto S, Miike T, Iwakiri H, Hasuike S, Nagata K, *Iwama A, Matsuda T, Kitanaka A, *Shimoda K.
TET2 is essential for survival and hematopoietic stem cell homeostasis.
Leukemia. 2012 Apr 3. doi: 10.1038/leu.2012.94. [Epub ahead of print].

Oki T, Kitaura J, Watanabe-Okochi N, Nishimura K, Maehara A, Uchida T, Komeno Y, Nakahara F, Harada Y, Sonoki T, Harada H, *Kitamura T.
Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis.
Leukemia. 26: 1038-1045. 2012.

Matsuda S, Kuwako KI, Okano HJ, Tsutsumi S, Aburatani H,Saga Y, Matsuzaki Y, Akaike A, Sugimoto H, *Okano H.
Sox21 Promotes Hippocampal Adult Neurogenesis via the Transcriptional Repression of the Hes5 Gene.
J Neurosci. 32(36):12543-12557. 2012.

*Kaneda A, Matsusaka K,Aburatani H, Fukayama M.
Epstein-barr virus infection as an epigenetic driver of tumorigenesis.
Cancer Res. 72(14): 3445-50. 2012.

Kuroda Y, Sako W, Goto S, Sawada T, Uchida D, Izumi Y, Takahashi T, Kagawa N, Matsumoto M, Matsumoto M, Takahashi R, Kaji R, *Mitsui T.
Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential.
Hum Mol Genet. 21: 991-1003, 2012.

Bhattacharyya J, * Mihara K, Kitanaka A, Yanagihara K, Kubo T, Takei Y, Kuroda T, Kimura A, Takihara Y.
T-cell immunotherapy with a chimeric receptor against CD38 is effective in eradicating refractory B-lymphoma cells overexpressing survivin induced by BMI-1.
Blood Cancer J. 2: e75. doi: 10.1038/bcj.2012.21. 2012.

Wada T, Kikuchi J, *Furukawa, Y.
Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8.
EMBO Rep. 13: 142-149, 2012.

Yae T, Tsuchihashi K, Ishimoto T, Motohara T, Yoshikawa M, Yoshida GJ, Wada T, Masuko T, Mogushi K, Tanaka H, Osawa T, Kanki Y, Minami T, Aburatani H, Ohmura M, Kubo A, Suematsu M, Takahashi K, *Saya H, *Nagano O.
Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell.
Nat Commun. 3:883. 2012.

Ueda Y, Katagiri K, Tomiyama T, Yasuda K, Habiro K, Katakai T, Ikehara S, Matsumoto M, *Kinashi T.
Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus.
Nat Commun. 3:1098.2012.

Sugihara E, Shimizu T, Kojima K, Ohishi N, Kai K, Ishizawa J, Nagata K, Hashimoto N, Honda, H, Kanno M, Miwa M, Okada S, Andreeff M, and *Saya H. Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor.
Oncogene, 31(23):2849-61.2012.

Shojima N, Hara K, Fujita H, Horikoshi M, Takahashi N, Takamoto I, Ohsugi M, Aburatani H, Noda M, Kubota N, Yamauchi T, Ueki K, *Kadowaki T.
Depletion of homeodomain-interacting protein kinase 3 impairs insulin secretion and glucose tolerance in mice.
Diabetologia. 55(12):3318-30. 2012

Tan SL, Nishi M, Ohtsuka T, Matsui T, Takemoto K, Kamio-Miura A, Aburatani H,Shinkai Y, *Kageyama R.
Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development.
Development. 139(20): 3806-16. 2012.

Azuma M, Koyama D, Kikuchi J, Yoshizawa H, Thasinas D, Shiizaki K, Kuro-o M, *Furukawa Y, Kusano E.
Promoter methylation confers kidney-specific expression of the Klotho gene.
FASEB J., 26:4264-74.2012.

*Takata H, Nishijima H,Maeshima K, *Shibahara K.
The integrator complex is required for integrity of Cajal bodies.
J Cell Sci. 125: 166-175, 2012.

Ohmori S, Takai J, Ishijima Y, Suzuki M, Moriguchi T, Philipsen S, Yamamoto M, *Ohneda K.
The regulation of GATA factor expression is distinct between erythroid and mast cell lineages.
Mol Cell Biol. 32(23):4742-55.2012.

Mimura I, Nangaku M, Kanki Y, Tsutsumi S, Inoue T, Kohro T, Yamamoto S, Fujita T, Shimamura T, Suehiro JI, Taguchi A, Kobayashi M, Tanimura K, Inagaki T, Tanaka T, Hamakubo T, Sakai J,Aburatani H, *Kodama T, *Wada Y.
Dynamic change of the chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of HIF1 and KDM3A.
Mol Cell Biol. 32(15): 3018-32. 2012.

Ainoya K, *Moriguchi T, Ohmori S, Souma T, Takai J, Morita M, Chandler KJ, Mortlock DP, Shimizu R, Engel JD, Lim KC, *Yamamoto M.
UG4 enhancer-driven GATA-2 and bone morphogenetic protein 4 complementation remedies the CAKUT phenotype in Gata2 hypomorphic mutant mice.
Mol Cell Biol. 32: 2312-2322. 2012.

Yamazaki H, Katsuoka F, Motohashi H, Engel JD, *Yamamoto M.
Embryonic lethality and fetal liver apoptosis in mice lacking all three small Maf proteins.
Mol Cell Biol. 32: 808-816. 2012.

Senga K, Mostov K E, Mitaka T,Miyajima A and *Tanimizu N.
Grainyhead-like 2 regulates epithelial morphogenesis by establishing functional tight junctions through the organization of a molecular network among claudin3, claudin4, and Rab25.
Mol Biol. Cell. 23: 2845-2855, 2012.

Tsumura M, Okada, S, Sakai H, Yasunaga S, Ohtsubo M, Murata T, Obata H, Yasumi T, Kong X, Abhyankar A, Heike T, Nakahata T, Nishikomori R, Al-Muhsen S, Boisson-Dupuis S, Casanova J-L, AlSherhri M, ElGhazali G,Takihara Y, * Kobayashi M. Dominant-negative STAT1 mutations in the SH2 domain predispose to mycobacterial diseases. 
Hum Mutat. 33: 1377-1387. 2012.

Lian G, Arimochi H, Kitamura A, Nishida J, Li S, Kishihara K, Maekawa Y, *Yasutomo K.
Manipulation of CD98 resolves type 1 diabetes in nonobese diabetic mice.
J Immunol. 188:2227-2234. 2012.

*Sato T, Chiba T, Ohno S, Sato C, Sugoh T, Miyashita K, Akatsuka H, Hozumi K, Okada Y, Iida Y, Akatsuka A, Agata Y, Chiba M, Kohu K, Satake M, Tanabe H, Saya H, Habu S.
Reciprocal control of G1-phase progression is required for Th-POK/Runx3-mediated CD4/8 thymocyte cell fate decision.
J Immunol. 189(9):4426-36. 2012.

Sakamoto S, Wakae K, Anzai Y, Murai K, Tamaki N, Miyazaki M, Miyazaki K, Romanow WJ,Ikawa T, Kitamura D, Yanagihara I, Minato N, Murre C, *Agata Y. 
E2A and CBP/p300 act in synergy to promote chromatin accessibility of the immunoglobulin κ Locus. 
J Immunol. 188: 5547-5560, 2012.

Ohtani M, Hoshii T, Fujii H, Koyasu S, Hirao A, Matsuda S*.
mTORC1 in Intestinal CD11c+CD11b+ Dendritic Cells Regulates Intestinal Homeostasis by Promoting IL-10 Production.
J Immunol. 188(10):4736-40. 2012.

Yamanishi Y, Takahashi M, Izawa K, Isobe M, Ito S, Tsuchiya A, Maehara A, Uchida T, Togami K, Enomoto Y, Nakahara F, Oki T, Kajikawa M, Kurihara H, *Kitamura T, *Kitaura J.
A soluble form of LMIR5/CD300b amplifies lipppolisaccharide-induced lethal inflammation in sepsis.
J Immunol. 189: 1773-1779. 2012.

Tanaka S, Saito Y, Kunisawa J, Kurashima Y, Wake T, Suzuki N, Shultz LD, Kiyono H, *Ishikawa F.
Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rγKO mice.
J Immunol. 188: 6145-6155. 2012

Sudo T, *Yokota T, Oritani K, Satoh Y, Sugiyama T, Ishida T, Shibayama H, Ezoe S, Fujita N, Tanaka H, Maeda T, Nagasawa T, Kanakura Y.
The endothelial antigen ESAM monitors hematopoietic stem cell status between quiescence and self-renewal.
J Immunol. 189: 200-210. 2012

Ishikawa-Kobayashi E, Ushijima K, Ando H, Maekawa T, Takuma M, Furukawa Y, *Fujimura A.
Reduced histone H3K9 acetylation of clock genes and abnormal glucose metabolism in ob/ob mice.
Chronobiol. Int. published online on August 14, 2012; DOI: 10.3109/07420528.2012.706765.

Yuda K, Takahashi H, Inoue T, Ueta T, Iriyama A, Kadonosono K, Tamaki Y, Aburatani H, Nagai R, *Yanagi Y.
Adrenomedullin Inhibits Choroidal Neovascularization via CCL2 in the Retinal Pigment Epithelium.
Am J Pathology.  2012 Jul 26. [Epub ahead of print]

Yagi K, Takahashi H, Akagi K, Matsusaka K, Seto Y, Aburatani H, Nakajima A, *Kaneda A.
Intermediate methylation epigenotype and its correlation to KRAS mutation in conventional colorectal adenoma.
Am J Pathology. 180(2): 616-25. 2012

Nagamine S, Tamba M, Ishimine H, Araki K, Shiomi K, Okada T, Ohto T, Kunita S, Takahashi S, Wismans RG, van Kuppevelt TH, *Masu M, *Keino-Masu K.
Organ-specific sulfation patterns of heparan sulfate generated by extracellular sulfatases Sulf1 and Sulf2 in mice.
J Biol Chem. 287: 9579-9590, 2012.

Hata S, Hirayama J, Kajiho H, Nakagawa K, Hata Y, Katada T, Furutani-Seiki M, *Nishina H.
A novel acetylation cycle of the transcription co-activator Yes-associated protein that is downstream of the Hippo pathway is triggered in response to SN2 alkylating agents.
J Biol Chem. 287: 22089-22098, 2012.

Uchida Y, Osaki T, Yamasaki T, Shimomura T, Hata S, Horikawa K, Shibata S, Todo T, *Hirayama J, Nishina H.
Involvement of the Stress Kinase Mitogen-activated Protein Kinase Kinase 7 in the Regulation of the Mammalian Circadian Clock.
J Biol Chem. 287: 8318-8326, 2012.__

*Nagamatsu G, Saito S, Kosaka T, Takubo K, Kinoshita T, Oya M, Horimoto K, Suda T.
Optimal ratio of transcription factors for somatic cell reprogramming.
J Biol Chem. 2012 Sep 6. [Epub ahead of print]

Komori T, Doi A, Nosaka T, Furuta H, Akamizu T, Kitamura T, Senba E, *Morikawa Y.
Regulation of AMP-activated protein kinase signaling by AFF4 protein, member of AF4 (ALL-fused gene from chromosome 4) family of transcription factors, in hypothalamic neurons.
J Biol Chem. 287: 19985-19996. 2012.

Kaneko H, Kobayashi E, *Yamamoto M, *Shimizu R.
N- and C-terminal transactivation domains of GATA1 protein coordinate hematopoietic program.
J Biol Chem. 287: 21439-21449. 2012.

Zhu N-L, Asahina K, Wang J, Ueno R, Lazaro R, Miyaoka Y, Miyajima A, and *Tsukamoto H.
Hepatic stellate cell-derived delta-like homolog 1 (DLK1) in liver regeneration.
J Biol Chem. 287: 10355-10367. 2012.

*Tanimizu N, Kikkawa Y, Mitaka T and Miyajima A.
α1- and α 5-containing laminins regulate the development of bile ducts via β1-integrin signals.
J Biol Chem. 287:_28586_28597. 2012.

Kuramoto T, Goto H, Mitsuhashi A, Tabata S, Ogawa H, Uehara H, Sijo A, Kakiuchi S, Maekawa, Yasutomo K, Hanibuchi M, Akiyama SI, Sone S, *Nishioka Y.
Dll4-Fc, an inhibitor of Dll4-Notch signaling, suppresses liver metastasis of small cell lung cancer cells through the downregulation of the NF-kappa-B activity
Mol Cancer Ther. 11(12):2578-87.2012

*Chauhan SC, Ebeling MC, Maher DM, Koch MD, Watanabe A, Aburatani H, Lio Y, *Jaggi M.
MUC13 mucin augments pancreatic tumorigenesis.
Mol Cancer Ther. 11(1): 24-33. 2012

Mizunaga Y, *Terai S, Yamamoto N, Uchida K, Yamasaki T, Nishina H, Fujita Y, Shinoda K, Hamamoto Y, Sakaida I.
Granulocyte colony-stimulating factor and interleukin-1b are important cytokine in repair of the cirrhotic liver after bone marrow cell infusion-comparison of humans and mice.
Cell Transplantation. 21(11):2363-75.2012.

Dan S, Okamura M, Mukai Y, Yoshimi H, Inoue Y, Hanyu A, Sakaue-Sawano A, Imamura T, Miyawaki A,
*Yamori T.
ZSTK474, a specific phosphatidylinositol 3-kinase inhibitor, induces G1 arrest of the cell cycle in vivo.
Eur J Cancer. 48: 936-943. 2012.

*Yoh K, Morito N, Ojima M, Shibuya K, Yamashita Y, Morishima Y, Ishii Y, Kusakabe M, Nishikii H, Fujita A, Matsunaga E, Okamura M, Hamada M, Suto A, Nakajima H, Shibuya A, Yamagata K, Takahashi S.
Overexpression of RORγt under control of the CD2 promoter induces polyclonal plasmacytosis and autoantibody production in transgenic mice.
Eur J Immunol. 42: 1999-2009. 2012.

Kawano H, Katayama Y, Minagawa K, Shimoyama M, Henkemeyer M, *Matsui T.
A novel feedback mechanism by Ephrin-B1/B2 in T-cell activation involves a concentration-dependent switch from costimulation to inhibition.
Eur J Immunol. 42: 1562-1572. 2012.

Prickaerts P, Niessen H, Mou-chel-Vielh E, Dahlmans V, Geijselaers C, Adriaens M, Spaapen F, Takihara Y, Rapp U, Peronnet F, * Voncken JW.
MK3 controls Polycomb-target gene expression via negative feedback on ERK.
Epigenetics & Chromatin. 5: 12. doi:10.1186/1756-8935-5-12. 2012. 

Okada K, *Kamiya A, Ito K, Yanagida A, Ito H, Kondou H, Nishina H, Nakauchi H.
Prospective isolation and characterization of bipotent progenitor cells in early mouse liver development.
Stem Cells and Development. 21: 1124-1133, 2012.

Shugo H†, Ooshio T†, Naito M, Naka K, Hoshii T, Tadokoro Y, Muraguchi T, Tamase A, Uema N, Yamashita T, Nakamoto Y, Suda T, Kaneko S, Hirao A*.
Nucleostemin in injury-induced liver regeneration.
Stem Cells Development, 21(16):3044-54.2012. †equally contribution

Shoji K, *Oda K, Kashiyama T, Ikeda Y, Nakagawa S, Sone K, Miyamoto Y, Hiraike H, Tanikawa M, Miyasaka A, Koso T, Matsumoto Y, Wada-Hiraike O, Kawana K, Kuramoto H, McCormick F, Aburatani H, Yano T, Kozuma S, Taketani Y.
Genotype-Dependent Efficacy of a Dual PI3K/mTOR Inhibitor, NVP-BEZ235, and an mTOR Inhibitor, RAD001, in Endometrial Carcinomas.
PLoS One. 7(5):e37431. 2012.

Higuchi T, *Sakamoto S, Kakinuma Y, Kai S, Yagyu K, Todaka H, Chi E, Okada S, Ujihara T, Morisawa K, Ono M, Sugiyama Y, Ishida W, Fukushima A, Tsuda M, Agata Y, Taniguchi T.
High expression of nuclear factor 90 (NF90) leads to mitochondrial degradation in skeletal and cardiac muscles.
PLoS One. 7: e43340, 2012.

Yokoi T, Seko Y, Yokoi T, Makino H, Hatou S, Yamada M, Kiyono T, Umezawa A, Nishina H, *Azuma N.
Establishment of Functioning Human Corneal Endothelial Cell Line with High Growth Potential.
PLOS ONE. 7: e29677, 2012.

Komada Y, Yamane T, Kadota D, Isono K, Takakura N, Hayashi SI, *Yamazaki H.
Origins and properties of dental, thymic, and bone marrow mesenchymal cells and their stem cells.
PLoS One. 7:e46436.2012.

Yamakawa N, Kaneda K, Saito Y, Ichihara E, *Morishita K.
The increased expression of integrin α6 (ITGA6) enhances drug resistance in EVI1(high) leukemia.
PLoS One. 7: e30706, 2012

Miyamoto M, Tsuboi Y, Honda K, Kobayashi M, Takamiya K, Huganir RL, Kondo M, Shinoda M, Sessle BJ, Katagiri A, Kita D, Suzuki I, Oi Y, *Iwata K.
Involvement of AMPA Receptor GluR2 and GluR3 Trafficking in Trigeminal Spinal Subnucleus Caudalis and C1/C2 Neurons in Acute-Facial Inflammatory Pain.
PLoS One.7: e44055. 2012

Iriuchishima H, *Takubo K (These two authors contributed equally to this work), Miyakawa Y, Nakamura-Ishizu A, Miyauchi Y, Fujita N, Miyamoto K, Miyamoto T, Ikeda E, Kizaki M, Nojima Y, *Suda T. 
Neovascular niche for human myeloma cells in immunodeficient mouse bone.
PLoS One. 7: e30557. 2012

Fujiwara T, Yokoyama H, Okitsu Y, Kamata M, Fukuhara N, Onishi Y, Fujimaki S, Takahashi S, Ishizawa K, Bresnick EH, *Harigae H.
Gene expression profiling identifies HOXB4 as a direct downstream target of GATA-2 in human CD34+ hematopoietic cells.
PLoS ONE. 7:e40959.2012.

Nakamura S, Oshima M, Yuan J, Saraya A, Miyagi S, Konuma T, Yamazaki S, Osawa M, Nakauchi H, Koseki H, *Iwama A.
Bmi1 confers resistance to oxidative stress on hematopoietic stem cells.
PLoS ONE. 7:e36209, 2012.

Ito S, Ishii A, Kakusho N, Taniyama C, Yamazaki S, Fukatsu R, Sakaue-Sawano A, Miyawaki A, *Masai H.
Mechanism of cancer cell death induced by depletion of an essential replication regulator.
PLoS One. e36372. 2012.

Tsuji S, Midorikawa Y, Takahashi T, Yagi K, Takayama T, Yoshida K, Sugiyama Y, *Aburatani H.
Potential responders to FOLFOX therapy for colorectal cancer by Random Forests analysis.
Br J Cancer. 106(1): 126-32. 2012

Bhattacharyya J, * Mihara K, Morimoto K,Takihara Y, Kimura A, Hide M.
Elevated Interleukin-18 secretion from monoclonal IgM+ B cells in a patient with Schnitzler syndrome. 
J Am Acad Dermatol. 67: e118-e120. 2012.

Li Q, Guo H, Matsui H, HondaH, Inaba T, Sundberg JP, Sprecher E *Uitto J. Mouse Samd9l is not a functional paralogue of the human SAMD9, the gene mutated in normophosphataemic familial tumoral calcinosis. (letter)
Exp. Dermatol. 21: 535-561. 2012

Mitsunaga K, Kikuchi J, Wada T, *Furukawa Y.
Latexin regulates the abundance of multiple cellular proteins in hematopoietic stem cells.
J. Cell. Physiol. 227: 1138-1147, 2012.

*Nagamatsu G, Kosaka T, Saito S, Takubo K, Akiyama H, Sudo T, Horimoto K, Oya M, Suda T.
Tracing the conversion process from primordial germ cells to pluripotent stem cells in mice.
Biol Reprod. 86: 182. 2012

Saito R, Nakauchi H, *>Watanabe S.
Serine/Threonine kinase Melk regulates proliferation and glial differentiation of retinal progenitor cells.
Cancer Sci. 103: 42-49. 2012.

Bhattacharyya J, * Mihara K, Ohtusbo M, Yasunaga S, Hoshi M, Takihara Y, Kimura A.
Overexpression of BMI-1 correlates with drug resistance in B-cell lymphomas through the stabilization of survivin expression.
Cancer Sci. 103: 34-41. 2012.

Kudo Y, *Tateishi K, Yamamoto K, Yamamoto S, Asaoka Y, Ijichi H, Nagae G, Yoshida H, Aburatani H, Koike K.
Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation.
Cancer Sci. 103(4): 670-6. 2012.

Kondo Y, Nagai K, Nakahata S, Saito Y, Ichikawa T, Suekane A, Taki T, Iwakawa R, Enari M, Taniwaki M, Yokota J, Sakoda S, *Morishita K.
Overexpression of the DNA sensor proteins, absent in melanoma 2 and interferon-inducible 16, contributes to tumorigenesis of oral squamous cell carcinoma with p53 inactivation.
Cancer Sci. 103: 782-90. 2012

Nakamura M, Kitaura J, Enomoto Y, Lu Y, Nishimura K, Isobe M, Ozaki K, Komeno Y, Nakahara F, Oki T, Kume H, Homma Y, *Kitamura T.
TSC-22 is a negative-feedback regulator of Ras/Raf signaling: Implications for tumorigenesis.
Cancer Sci. 103: 26-33. 2012.

Iwagawa T, Ohuchi S, Watanabe S, *Nakamura Y.
Selection of RNA aptamers against mouse embryonic stem cells.
Biochimie, 94: 250-257, 2012

Baba,Y, Satoh S, Otsu M, Sasaki E, Okada T, and *Watanabe S.
In vitro cell subtype-specific transduction of adeno-associated virus in the mouse and marmoset retinal explant culture,
Biochimie, 94(12):2716-22.2012.

Seo W, Tanaka H, Miyamoto C, Levanon D, Groner Y and *Taniuchi I.
Roles of VWRPY-motif-mediated gene repression by Runx proteins during T cell development.
Immunol. Cell Biol. 90:827-30.

Iwamoto T, *Terai S, Mizunaga Y, Yamamoto N, Omori K, Uchida K, Yamasaki T, Fujii Y, Nishina H, Sakaida I.
Splenectomy enhances the anti-fibrotic effect of bone marrow cell infusion and improves liver function in cirrhotic mice and patients.
J Gastroenterol. 47: 300-312, 2012.

Isobe K, Kawano H, Takeda T, Suda A, Kumagai A, Mizuno H, Miyawaki A, *Midorikawa K.
Background-free deep imaging by spatial overlap modulation nonlinear optical microscopy.
Biomed Opt Express. 3:1594-1608.2012.

Tsuji S, Ihara S, *Aburatani H.
A simple knowledge-based mining method for exploring hidden key molecules in a human biomolecular network.
BMC Syst Biol. 6(1): 124. 2012.

Ikejiri A, Nagai S, Goda N, Kurebayashi Y, Osada-Oka M, Takubo K, Suda T, *Koyasu S.
Dynamic regulation of Th17 differentiation by oxygen concentrations.
Int Immunol. 24: 137-146. 2012

Shibata T, Takamura N, Motoi Y, Goto Y, Karuppuchamy T, Izawa K, Akashi-Takamura S, Tanimura N, Kunisawa J, Kiyono H, Akira S, Kitamura T, Kitaura J, Miyake K.
PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells.
Int Immunol. 24(10):613-23. 2012.

*Hayashi T, Horiuchi A, Sano K, Hiraoka N, Kasai M, Ichimura T, Sudo T, Nishimura R, Ishiko O, Shiozawa T, Kanai Y, Yaegashi N, Aburatani H, Konishi I.
Potential role of LMP2 as an anti-oncogenic factor in human uterine leiomyosarcoma: Morphological significance of calponin h1.
FEBS Lett. 586(13): 1824-31. 2012.

Adamczyk A, Mejias R, Takamiya K, Yocum J, Krasnova IN, Calderon J, Cadet JL, Huganir RL, Pletnikov MV, *Wang T.
GluA3-deficiency in mice is associated with increased social and aggressive behavior and elevated dopamine in striatum.
Behav Brain Res. 229: 265-72. 2012

Hutchins AP, Poulain S, Fujii H, *Miranda-Saavedra D.
Discovery and characterization of new transcripts from RNA-seq data in mouse CD4(+) T cells.
Genomics. 100(5):303-13.2012.

Ishijima Y, Ohmori S, Uenishi A, *Ohneda K.
GATA transcription factors are involved in IgE-dependent mast cell degranulation by enhancing the expression of phospholipase C-γ1.
Genes Cells.17:285-301.2012.

Juliana FM, Nara H, Onoda T, Rahman M, Araki A, Jin L, Fujii H, Tanaka N, Hoshino T, *Asao H.
Apurinic/apyrimidinic endonuclease1/redox factor-1 (Ape1/Ref-1) is essential for IL-21-induced signal transduction through ERK1/2 pathway.
Biochem Biophys Res Commun. 420: 628-634. 2012

Oishi T, Terai S, Kuwashiro S, Fujisawa K, Matsumoto T, Nishina H, Sakaida I.
Ezetimibe reduces fatty acid quantity in liver and decreased inflammatory cell infiltration and improved NASH in medaka model.
Biochem Biophys Res Commun. 422: 22-27, 2012.

Hara-Miyauchi C, Tsuji O, Hanyu A, Okada S, Yasuda A, Fukano T, Akazawa C, Nakamura M, Imamura T, Matsuzaki Y, Okano HJ, Miyawaki A, *Okano H.
Bioluminescent system for dynamic imaging of cell and animal behavior.
Biochem Biophys Res Commun. 419: 188-193. 2012.

Sakai S, Nakaseko C, Takeuchi M, Ohwada C, Shimizu N, Tsukamoto S, Kawaguchi T, Jiang M, Sato Y, Ebinuma H, Yokote K, Iwama A, Fukamachi I, Schneider WJ, Saito Y,  *Bujo H.
Circulating soluble LR11/SorLA levels are highly increased and ameliorated by chemotherapy in acute leukemias.
Clinica Chemica Acta. 413:1542-1548, 2012.

Bhattacharyya J, * Mihara K, Takihara Y, Kimura A.
Successful treatment of IgM-monoclonal gammopathy of undetermined significance associated with cryoglobulinemia and cold agglutinin disease with immunochemotherapy with rituximab, fludarabine, and cyclophosphamide.
Ann Hematol. 91: 797-799. 2012.

Inokura K, *Onishi Y, Shimosegawa K, Okitsu Y, Katsuoka Y, Fujiwara T, Fukuhara N, Ishizawa K, Harigae H.
Philadelphia-negative acute promyelocytic leukemia in a patient with chronic myeloid leukemia in complete cytogenetic response after treatment with tyrosine kinase inhibitor.
Ann Hematol. 91(11):1825-6.2012.


Shi L, Fujioka K, Sun J, Kinomura A, Inaba T, Ikura T, Ohtaki M, Yoshida M, Kodama Y, Livingston GK, Kamiya K, *Tashiro S. A modified system for analyzing ionizing radiation-induced chromosome abnormalities.
Radiat Res. 177: 533-538. 2012

Suzuki K, Ono R, Ohishi K, Masuya M, Kataoka I, Liu B, Nakamori Y, Ino K, Monma F, Hamada H, Kitamura T, Katayama N, Nosaka T.
IKAROS isoform 6 enhances BCR-ABL-mediated proliferation of human CD34+ hematopoietic cells on stromal cells.
Int J Oncol. 40: 53-62. 2012.

Shibata-Minoshima F, Oki T, Doki N, Nakahara F, Kageyama S, Kitaura J, Fukuoka J, *Kitamura T.
Identification of RHOXF2 (PEPP2) as a cancer-promoting gene by expression cloning.
Int J Oncol. 40: 93-98. 2012.

Niizuma S, Inuzuka Y, Okuda J, Kato T, Kawashima T, Tamaki Y, Iwanaga Y, Yoshida Y, Kosugi R, Watanabe-Maeda K, Machida Y, Tsuji S, Aburatani H, Izumi T, Kita T, Kimura T, *Shioi T.
Effect of persistent activation of phosphoinositide 3-kinase on heart.
Life Sci. 90(15-16): 619-28. 2012.

Oishi H, Itoh S, Matsumoto K, Ishitobi H, Suzuki R, Ema M, Kojima T, Uchida K, Kato M, Miyata T, *Takahashi S.
Delayed cutaneous wound healing in Fam129b/Minerva-deficient mice.
J. Biochem. 152:549-55.2012.

Tojo M, Takebe A, Takahashi S, Tanaka K, Imamura T, *Miyazono K, *Chiba T.
Smad7-deficient mice show growth retardation with reduced viability.
J Biochem. 151: 621-631, 2012.

Matsumoto K, Azami T, Otsu A, Takase H, Ishitobi H, Tanaka J, Miwa Y, Takahashi S, *Ema M.
Study of normal and pathological blood vessel morphogenesis in Flt1-tdsRed BAC Tg mice.
Genesis. 50: 561-571. 2012.

Gupta BK, Maher DM, Ebeling MC, Sundram V, Koch MD, Lynch DW, Bohlmeyer T, Watanabe A, Aburatani H, Puumala SE, Jaggi M, *Chauhan SC.
Increased Expression and Aberrant Localization of Mucin 13 in Metastatic Colon Cancer.
J Histochem Cytochem. 2012 Aug 20. [Epub ahead of print]

Okamoto A, Torigata K, Sakurai MA, Okuzaki D, Fujii H, Ohmine T, Miura D, Kimura S, Yabuta N, *Nojima H. 
A simple and efficient method for the preparation of live leukocytes from peripheral blood using the LeukoCatchTM system.
Adv. Biosci. Biotechnol. 3.630-642.2012.

*Tsuchiya A, Imai M, Kamimura H, Takamura M, Yamagiwa S, Sugiyama T, Nomoto M, Heike T, Nagasawa T, Nakahata T, Aoyagi Y.
Increased Susceptibility to Severe Chronic Liver Damage in CXCR4 Conditional Knock-Out Mice.
Dig Dis Sci. 57:2892-900.2012.

Fujita T, *Fujii H.
Transcription start sites and usage of the first exon of mouse Foxp3 gene.
Mol Biol Rep. 39: 9613-9619. 2012

Suzuki E, Chiba T, Zen Y, Miyagi S, Tada M, Kanai F, Imazeki F, Miyazaki M, Iwama A,  *Yokosuka O.
Aldehyde dehydrogenase 1 is associated with recurrence-free survival but not stem cell-like properties in hepatocellular carcinoma.
Hepatol Res. 2012 Apr 13. doi: 10.1111/j.1872-034X.2012.01028.x. [Epub ahead of print]

Ashinuma H, *Takiguchi Y, Kitazono S, Kitazono-Saitoh M, Kitamura A, Chiba T, Tada Y, Kurosu K, Sakaida E, Sekine I, Tanabe N, Iwama A, Yokosuka O, *Tatsumi K. Anti-proliferative action of metformin in human lung cancer cell lines.
Oncology Reports. 28: 8-14, 2012.

Ikeda Y, Oda K, Nakagawa S, Murayama-Hosokawa S, Yamamoto S, Ishikawa S, Wang L, Takazawa Y, Maeda D, Wada-Hiraike O, Kawana K, Fukayama M, Aburatani H, Yano T, Kozuma S, Taketani Y.
Genome-wide single nucleotide polymorphism arrays as a diagnostic tool in patients with synchronous endometrial and ovarian cancer.
Int J Gynecol Cancer. 22(5): 725-31. 2012

Iguchi-Ishiguro H, Ouchi Y, *Watanabe S, Numabe Y.
Analysis of syndecan-1 gene promoter during mouse tooth development.
Archives of Oral Biology. 57: 531-538. 2012.

Enomoto Y, Kitaura J, Shimanuki M, Kato N, Nishimura K, Takahashi M, Nakamura H, *Kitamura T, *Sonoki T.
MicroRNA-125b-1 accelerates a C-terminal mutant of C/EBPα (C/EBPα-C(m))-induced myeloid leukemia.
Int J Hematol. 96: 334-341. 2012.

Doki N, Kitaura J, Inoue D, Kato N, Kagiyama Y, Uchida T, Togami K, Isobe M, Ito S, Maehara A, Izawa K, Oki T, Harada Y, Nakahara F, Harada H *Kitamura T. 
Fyn is not essential for Bcr-Abl-induced leukemogenesis in mouse bone marrow transplantation models.
Int J Hematol. 95: 167-175. 2012.

*Yazaki M, Kamei M, Ito Y, Konno Y, Wang RN, Toki T, Ito E.
A novel mutation of ribosomal protein S10 gene in a Japanese patient with Diamond-Blackfan anemia.
J Pediatr Hematol Oncol. 34:293-295. 2012.


*Yamada-Fujiwara M, Miyamura K, Fujiwara T, Tohmiya Y, Endo K, Onishi Y, Ishizawa K, Kameoka J, Ito M, Harigae H.
Diagnosis of intestinal gtaft-versus-host disease and thrombotic microangipathy after allogeneic stem cell transplantation.
Tohoku J Exp Med . 227: 31-37. 2012.

Uchida Y, Shimomura T, *Hirayama J, Nishina H.
Light, reactive oxygen species, and magnetic fields activate ERK/MAPK signaling pathway in cultured zebrafish cells.
Appl. Magn. Reson. 42: 69-77, 2012.

Nakahata S, *Morishita K.
CADM1/TSLC1 is a novel cell surface marker for adult T-cell leukemia/lymphoma.
J Clin Exp Hematop. 52: 17-22. 2012

Fujita A, Yoh K, Shimohata H, Morito N, Ojima M, Okamura M, Takahashi S, *Yamagata K.
A novel diabetes mellitus mouse model, MafA-deficient and beta cell-specific MafK-overexpressing hybrid transgenic mice, developed severe diabetic nephropathy and improved with TCV-116 (candesartan cilexetil) treatment.
Exp Animal. 61: 49-57. 2012.

Sekiguchi Y, Owada J, *Oishi H, Katsumata T, Ikeda R, Kudo T, *Takahashi S.
Noninvasive monitoring of _-cell mass and fetal _-cell genesis in mice using bioluminescence imaging.
Exp Animal. 61: 445-451. 2012.


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